Behavioral and fMRI Study: Social Reciprocity in Schizotypal Personality Disorder

描述(申请人提供)：社交障碍是分裂型的一个显著特征 人格障碍(SPD)，通常表现为朋友很少，长时间 失业。假设输入和输出的情绪处理缺陷相结合 解释SPD受试者的社会和职业失败。在此R21重新提交申请中 情绪性面孔和韵律的简单感觉输入和运动输出将在SPD和 控制受试者。主要的假设是，与对照组相比，DSM-IV诊断了SPD患者 受试者将表现出对社会互惠(即感官)至关重要的信息处理的缺陷 面部情绪和情绪韵律的处理)，以及运动信号输出的缺陷 与社会互惠(即面部表情和声音变化)有关，这是传达信息所需的 社会意义和情感意义。这四个方面的社会互惠将被研究使用行为 测量，计算机衍生的情感表达任务，录像带，音调分析(测量 韵律)，以及结构和功能磁共振成像(FMRI)。为了实现这些目标，24名天真的神经衰弱患者 SPD受试者年龄、性别、父母社会经济状况与24名对照受试者相匹配，将 从社区招募。研究SPD受试者的另一个理由是他们不是精神病患者 也没有接受过抗精神病药治疗。然而，SPD受试者具有相同的遗传素质 精神分裂症，因此提供了一个独特的机会来检查行为和功能 精神分裂症谱系障碍的神经解剖学，没有多项研究，例如 严重精神疾病引起的药物效应和压力。与NIMH的使命相关： 了解SPD中社会互惠的基本异常现象可能会产生重大影响 关于我们对精神分裂症的这些缺陷的概念化，这反过来可能会刺激进一步的社会 康复研究。

DESCRIPTION (provided by applicant): Social impairment is a prominent feature of schizotypal personality disorder (SPD) and is often manifested in subjects by having few friends and long periods of unemployment. It is hypothesized that a combination of input and output emotional processing deficits explains the social and occupational failure of SPD subjects. In this R21 resubmission application simple sensory input and motor output of emotional faces and prosody will be compared in SPD and control subjects. The main hypothesis is that DSM-IV diagnosed SPD subjects, compared with control subjects, will exhibit deficits in information processing essential to social reciprocity (i.e., sensory processing of facial emotions and emotional prosody), and also deficits in the motoric output of signals related to social reciprocity (i.e., facial expressions and voice inflection), which are needed to convey social and emotional meaning. These four aspects of social reciprocity will be studied using behavioral measures, a computer-derived emotional expression task, videotapes, pitch analysis (measure of prosody), as well as by structural and functional MRI (fMRI). To achieve these aims, 24 neurolepticnaive SPD subjects age, gender, parental socio- economically matched to 24 comparison subjects, will be recruited from the community. A further rationale for studying SPD subjects is they are not psychotic and have not received neuroleptic medications. Yet SPD subjects share the same genetic diathesis as schizophrenia, and thus offer a unique opportunity to examine the behavior and the functional neuroanatomy of schizophrenia spectrum disorders, without multiple researches confounds such as medication effects and stress due to serious mental illness. Relevance to NIMH's mission: Understanding fundamental abnormalities in social reciprocity in SPD could have a significant impact on our conceptualization of these deficits in schizophrenia, which, in turn, might stimulate further social rehabilitation research.