Human arylamine N-acetyltransferase regulation and function - effect of genetic poymorphisms.

我们如何处理进入我们体内的化学物质取决于一系列负责分解化学物质并消除它们的酶。这些酶的活性因人而异，因此我们对化学品和药物的反应因人而异。一些酶因遗传突变而变化，但其他酶因我们的饮食和生活环境而变化。该项目将研究一种称为乙酰基转移酶的主要酶，该酶被认为是癌症，哮喘，肝硬化和药物不良反应等疾病的风险因素。我们计划研究细胞中的酶，并确定哪些环境因素导致了个体之间的变异，以及这如何影响其基因中发现的基因突变。通过这些研究，我们将更好地了解不同的人如何代谢外来化学物质，并应该能够预测哪些人最有可能患某些疾病。

How we handle chemicals that enter our bodies depends on a series of enzymes that are responsible for breaking down the chemicals and eliminating them. The activity of many of these enzymes varies between individuals so our responses to chemicals and drugs is different for each individual. Some of the enzymes vary because of inherited mutations, but others vary because of the diets we eat and the environment in which we live. This project will investigate a major enzyme called acetlytransferase that has been implicated as a risk factor in diseases such as cancer, asthma, liver cirrhossis and adverse drug reactions. We plan to look at the enzyme in cells and determine what environmental factors contribute to its variation between individuals, and how this impacts on the genetic mutations that have been found in its gene. From these studies, we will have a much better undersanding of how different people metabolise foreign chemicals, and should be able to predict those most at risk of certain diseases.