Training in Molecular Basis of Skin Pathobiology

描述（由申请人提供）：俄勒冈健康与科学大学皮肤学系提出了一个新的培训计划，目标是为皮肤基础和转化研究的学术事业培养高素质的博士前和博士后。OHSU皮肤科在临床和科学研究方面有着悠久的历史，在皮肤科住院医师培训方面有着40年的历史。建议项目的特点是：1)皮肤科核心教师，包括分别具有24年和14年皮肤研究和指导经验的项目主任Kulesz-Martin博士（皮肤癌，肿瘤抑制因子p53）和副主任Wang Xiao-Jing（皮肤癌的表皮基因开关转基因模型和tgf - β /SMAD通路），Steven Jacques（皮肤光学成像）和Melissa Wong （β -catenin通路，干细胞）；2)在与皮肤细胞生长、分化和凋亡高度相关的领域拥有国际认可的多学科科学家团队，包括Hua Lu (p63和p53), Bruce Magun （tgf - β和应激激酶反应），Peter Rotwein（胰岛素样生长因子/IGFs分化），组织生长和再生)和Philip Stork（生长和凋亡中的Ras和B-Raf信号）和3)新设计的研究空间总计约6000平方英尺（皮肤病学4500平方英尺，OHSU癌症研究所1500平方英尺）。三名博士后和两名博士预科生将从医学博士、博士或医学博士/博士候选人中选出，他们希望在调查皮肤病学或基础皮肤研究方面从事学术工作，并具有很强的临床转化成分。标准将包括独立潜力、推荐信、发表记录、在皮肤病学领域具有强大影响潜力的专业知识，以及向服务不足的少数群体伸出援手。培训计划包括OHSU的研究生课程，导师所在部门的研讨会（皮肤病学，细胞与发育生物学，生物化学，分子与医学遗传学），每月皮肤病学研究部门会议和技术研讨会，为博士生或博士后学生量身定制的研究论坛以及皮肤生物学的国家/国际会议。

DESCRIPTION (provided by applicant): The Oregon Health & Science University Department of Dermatology proposes a new training program with objectives to train highly qualified predoctoral and postdoctorals for academic careers in skin basic and translational research. The OHSU Dermatology Department has a strong history of clinical and scientific research and a 40 year record in dermatology resident training. Features of the proposed program are: 1) a core of Dermatology faculty, including program director Dr. Kulesz-Martin (skin carcinogenesis, tumor suppressor p53), and Co-Director Xiao-Jing Wang (epidermal gene-switch transgenic models of skin carcinogenesis and TGF-beta/SMAD pathways in skin disease) with 24 and 14 years experience in skin research and mentorship, respectively, Steven Jacques (cutaneous optical imaging), and Melissa Wong (Beta-catenin pathway, stem cells), 2) a multidisciplinary team of scientists with international recognition in areas highly relevant to skin cellular growth, differentiation and apoptosis, including Hua Lu (p63 and p53), Bruce Magun (TGF-beta and stress kinase responses), Peter Rotwein (insulin-like growth factors/IGFs in differentiation, tissue growth and regeneration) and Philip Stork (Ras and B-Raf signaling in growth and apoptosis) and 3) newly designed research space totaling approximately 6000 sq ft (4500 sq ft in Dermatology and 1500 sq ft of OHSU Cancer Institute space). Three postdoctoral and two pre-doctoral trainees will be selected from M.D., Ph.D. or M.D./PhD candidates who desire an academic career in investigative dermatology or basic skin research with strong clinical translational component. Criteria will include potential for independence, letters of recommendation, publication record, expertise of strong potential for impact in dermatology and outreach to underserved minorities. The training program includes graduate courses at OHSU, seminars in mentors' departments (Dermatology, Cellular & Developmental Biology, Biochemistry, Molecular & Medical Genetics), monthly Dermatology Research Division meetings and techniques seminars, research forums tailored to predoctoral or postdoctoral students and national/international meetings in cutaneous biology.