Training in Drug Abuse and Brain Imaging

描述（由申请人提供）：申请继续开展脑成像和药物滥用博士后研究培养计划。我们有各种各样的大脑成像工具，这些工具已经提供了关于大脑奖励系统和成瘾的有价值的信息。对这样一个专门的项目的需求是由新的和创新的技术的出现决定的，这些技术可以在各种与药物滥用相关的条件下观察大脑的解剖和功能方面，例如：急性中毒效应，跟踪线索诱导的渴望，测量认知效应，检测持续的神经和认知缺陷，监测戒断，睡眠障碍，药物依从性，跟踪治疗进展和药物开发。由于涉及成像的学科的性质和范围是复杂的，因此需要具有成像技术、神经科学、药理学、成瘾医学和治疗背景的新一代科学家来更充分地探索药物滥用的神经生物学基础，并填补美国研究中心的预期空缺——本培训计划旨在填补这一空白。在过去的4年里，我们建立了一个综合的、多学科的药物滥用和脑成像培训计划（DABITP），由麦克莱恩医院/哈佛医学院和波士顿大学医学院联合支持。在过去的一年里，我们一直在进行转化研究，并将于2006年11月安装一个9.4T的磁铁。预期NIDA的使命是加强临床前研究与临床研究的整合，我们在培训计划中增加了一个新的轨道。此外，我们还与东北大学药物发现中心合作，共同申请P20，并开始利用彼此的资源，加强转化研究方面的培训。我们为期2-3年的博士后培训计划旨在为学员提供MR和EEC技术的基础知识，然后在满足学员特定职业目标的四个不同研究方向之一进行安置：1)MR技术和仪器；2)基础临床；3)临床治疗；4)翻译。脑成像和精神药理学的教学训练与各种非常成功的研究实验室的实际应用相结合，将为我们的学员提供运用脑成像技术的技能，因为他们开始了下一个十年对成瘾大脑的研究。

DESCRIPTION (provided by applicant): This is a proposal to continue a postdoctoral research-training program in brain imaging and drug abuse. We have at our disposal a variety of brain imaging tools that have yielded valuable information about brain reward systems and addiction. The need for such a dedicated program is dictated by the emergence of new and innovative techniques to view both the anatomical and functional aspects of the brain under a variety of conditions related to substance abuse such as: acute intoxicating effects, tracking cue-induced craving, measuring cognitive effects, detecting persistent neurological and cognitive defects, monitoring withdrawal, sleep disturbances, medication compliance, tracking treatment progress and medication development. Because the nature and spectrum of the disciplines involved in imaging are complex, a new breed of scientists with backgrounds in imaging technology, neuroscience, pharmacology, addiction medicine and treatment will be needed to more fully explore the neurobiological bases of drug abuse and fill the anticipated vacancies in research centers in the United States-this Training Program is designed to fill this void. Over the past 4 years we established an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program (DABITP) that was jointly supported by the McLean Hospital/Harvard Medical School and Boston University School of Medicine. In the past year we have engaged in translational research and will be installing a 9.4T magnet in November 2006. In anticipation of NIDA's mission to enhance the integration of preclinical with clinical research, we have added a new track to our training program. In addition, we also have teamed with the Center for Drug Discovery at Northeastern University in a joint P20 application and have begun to tap into each other's resources to enhance training in translational research. Our 2-3 year postdoctoral training program is structured to provide the trainees with the basics of MR and EEC techniques, which is followed by placement in one of four distinct research tracks that meets the trainees' specific career goals: 1) MR Technology and Instrumentation; 2) Basic Clinical; 3) Clinical Treatment; and 4) Translational. The combination of didactic training in brain imaging and psychopharmacology with practical applications in a variety of highly successful research laboratories will provide our trainees with the skills to employ brain imaging techniques as they embark on the next decade of research on the addicted brain.