Graduate Training in Cancer Cell Biology

描述(由申请人提供)：本提案要求继续支持基础癌细胞生物学的博士前培训计划。该计划的目标是为在学术机构或行业从事基础或临床相关癌症研究的博士科学家做准备。培训人员来自细胞和分子医学(DCMM)、医学和生物系、摩尔加州大学圣迭戈分校癌症中心、路德维希癌症研究所(LICR)和霍华德·休斯医学院(HHMI)。教师队伍已经大大扩大，包括活跃在基础和临床前转化性癌症研究的教师。该课程是医学院唯一的癌症博士前培训课程，并被整合到生物医学(BMS)研究生课程中，因此建立在细胞和分子生物学、遗传学、免疫学、药理学和生理学的广泛基础课程的基础上并与之相结合。培训人员强烈认为，要治愈癌细胞中发生的细胞过程紊乱，需要详细了解正常和异常细胞行为的分子、细胞和遗传学方面，以及它们在癌症研究中的应用。每一位教师都在其所在领域获得国际认可，拥有卓越的培训记录，并拥有对了解癌症细胞生物学至关重要的研究兴趣-包括细胞周期控制、癌基因和抗癌基因、调节激酶、信号、生长控制、G蛋白和RGS蛋白、细胞运动控制、癌细胞的糖生物学、肿瘤内皮生长因子的肿瘤产生、肿瘤血管形成、细胞和分子基因组学，以及实验性抗癌疗法的发展。那些在BMS研究生课程的第一年表示有兴趣从事基础癌细胞生物学论文研究的人，是根据他们的学术和研究表现来选择支持的。学员必须完成BMS研究生课程要求和专门的癌症实习生课程要求，包括癌症研究课程、负责任的研究行为、关于癌症细胞/分子生物学的教程和小组会议、参加DCMM联合研讨会系列以及关于癌症临床方面和肿瘤细胞对各种治疗的反应的研讨会系列。

DESCRIPTION (provided by applicant): This proposal requests continuing support for a predoctoral training program in basic Cancer Cell Biology. The program goal is to prepare Ph.D. scientists for careers in basic or clinically-related Cancer Research in academic institutions or industry. The training faculty are drawn from the Departments of Cellular and Molecular Medicine (DCMM), Medicine and Biology, the Moores UCSD Cancer Center, the Ludwig Institute for Cancer Research (LICR), and the Howard Hughes Medical Institute (HHMI). The faculty has been greatly expanded to include faculty active in both basic and preclinical translational cancer research. This program is the only predoctoral cancer training program based in the School of Medicine and is integrated into the Biomedical Sciences (BMS) Graduate Program and is therefore built on and integrated within a broadly based program in cell and molecular biology, genetics, immunology, pharmacology and physiology. The training faculty strongly believes that to cure the derangements of cell processes that occur in cancer cells requires detailed understanding of the molecular, cellular and genetic aspects of both normal and abnormal cell behavior and their application to cancer research. Each of the faculty is internationally recognized in his/her field, has an outstanding training record, and has research interests that are fundamental to understanding cancer cell biology- including cell cycle control, oncogenes and anti-cancer genes, regulatory kinases, signaling, growth control, G proteins and RGS proteins, control of cell movement, glycobiology of cancer cells, tumor production of endothelial growth factors, tumor vascularization, cellular and molecular genomics, and the development of experimental anticancer therapeutics. Those individuals who during their first year in the BMS graduate program express an interest in undertaking thesis research in basic cancer cell biology are selected for support based on the strength of their academic and research performance. Trainees are required to complete both the BMS Graduate Program requirements and the specialized Cancer Trainee Program requirements, including courses in Cancer Research, the Responsible Conduct of Research, tutorials and small group conferences on the cellular/molecular biology of cancer, and attendance at the joint DCMM seminar series as well as a seminar series on the clinical aspects of cancer and the response of tumor cells to various treatments.