Cancer Cell Biology Training Program

描述(由申请人提供)：本提案是为了继续在北卡罗来纳大学教堂山分校(UNC-CH)为博士前学生提供跨学科的癌症细胞生物学培训计划。该项目的前提是，北卡罗来纳大学-CH分校的博士生在分子和细胞生物学范式方面接受了良好的培训，但这些学生很少接受过癌症病理生物学和治疗方面的重要培训。随着对转化性、以疾病为导向的研究的日益重视，解决研究生培训中这一不足的必要性变得更加紧迫。因此，这个项目的广泛目标是提供癌症生物学的全面培训，使学生能够有效地为新一轮的翻译研究做出贡献。该课程着重于癌症的组织病理学，并让学员接触到肿瘤生物学的关键主题，包括血管生成、侵袭性、转移、癌症化疗和抗癌药物的发现。因此，它促进了对博士生的培训，这些博士生受到独特的培训，并与北卡罗来纳大学国家卫生研究院资助的个别部门或其他培训项目明显区分开来。这一计划得到了北卡罗来纳大学CH分校卓越的教职员工以及著名的莱恩伯格综合癌症中心(LCCC)提供的领导力和计划的补充。39名讲师来自10个不同的北卡罗来纳大学-CH部门和3个跨学科的博士前培训课程。项目负责人也是LCCC的成员。这一培训计划的一个关键组成部分是建立癌症细胞生物学课程，其中包括专门为计划学员开发的课程，这些课程解决了癌症病理学、诊断、药物发现和治疗方面的关键问题。这一博士后项目得到了为LCCC长期博士后培训项目开发的项目的有力补充。因此，这两个培训计划一起促进了LCCC的目标，即创建一个全面的、跨学科的、有凝聚力的和协作的研究环境，以促进博士后和博士后癌症研究人员的发展。

DESCRIPTION (provided by applicant): This proposal is for continuation of an interdisciplinary Cancer Cell Biology Training Program for predoctoral ludents at the University of North Carolina at Chapel Hill (UNC-CH). The premise of this program is that the doctoral students graduated by UNC-CH are well trained in the paradigms of molecular and cellular biology, but rarely do these students receive significant training in the pathobiology and treatment of cancer. With an increasing emphasis on translational, disease-oriented research, the need to address this deficiency in graduate student training has become of greater urgency. Thus, the broad goal of this program is to provide comprehensive training in cancer biology to allow students to effectively contribute to the new wave of translational research. The program provides a strong emphasis on the histopathology of cancer and the exposure of trainees to topics crucial to tumor biology, including angiogenesis, invasiveness, metastasis, cancer chemotherapy, and cancer drug discovery. Therefore, it fosters the training of doctoral candidates that are uniquely trained and clearly distinguished from those of individual departments or other training programs funded by the NIH at UNC-CH. This program is complemented by the excellence of the faculty at UNC-CH and the leadership and programs provided by the well-established Lineberger Comprehensive Cancer Center (LCCC). The 39 faculty preceptors are drawn from 10 different UNC-CH departments and three interdisciplinary predoctoral training curricula. Program preceptors are also members of the LCCC. A critical component of this training program is the establishment of a Cancer Cell Biology Curriculum that includes coursework developed specifically for the Program trainees that address key issues in cancer pathology, diagnosis, drug discovery and treatment. This predoctoral program is strongly complemented by the programs that have been developed for the LCCC's long-standing postdoctoral training program. Thus, together, these two training programs facilitate the LCCC's goal to create a comprehensive, interdisciplinary, cohesive and collaborative research environment to foster the development of both pre- and postdoctoral cancer researchers.