Cancer Cell Biology Training Program

描述（由申请人提供）：过去几十年的研究在我们对癌症的遗传基础以及驱动癌症进展和恶性生长的异常信号传导组分和机制的理解方面取得了令人印象深刻的进展。近年来，人类基因组测序的完成，以及最近多个癌细胞基因组测序的完成，加上癌细胞全基因组遗传、细胞和生物化学分析技术的快速发展，大大加速了这些进展。这一速度在未来肯定会成倍加快。新信息的积累既令人印象深刻，又令人生畏。因此，下一个十年的主要挑战将是将基础癌症研究进展转化为新的分子靶向癌症疗法。癌症细胞生物学培训计划（CCBTP）的前提是癌症生物学是一门独特的跨学科生物医学科学，包括细胞生物学，分子生物学，生物化学，遗传学，免疫学，微生物学，药理学，流行病学，毒理学，病理学和生理学的实验方法和教学知识。博士生将成为训练有素的分子和细胞生物学的范式，从更传统的部门或学院为基础的培训计划。他们很少会在病理生物学和癌症治疗方面接受重要的培训。随着对多学科，转化，以疾病为导向的研究越来越重视，需要解决这一不足，在研究生培养已变得更加紧迫。因此，该计划的广泛目标是提供转化癌症生物学的全面培训，使学生能够有效地为转化研究的新浪潮做出贡献。CCBTP非常重视癌症的组织病理学和对肿瘤生物学至关重要的其他主题的暴露，特别是个性化医疗和分子靶向抗癌药物的发现和开发。因此，它促进了博士候选人的培训，这些博士候选人受过独特的训练，并与查佩尔山的北卡罗来纳州大学国立卫生研究院资助的个别部门或其他培训项目有明显的区别

DESCRIPTION (provided by applicant): Research during the past several decades has made impressive advances in our understanding of the genetic basis of cancer and the aberrant signaling components and mechanisms that drive cancer progression and malignant growth. In recent years, the completion of the sequencing of the human and more recently, of multiple cancer cell genomes, coupled with the rapid development of technologies for the genome-wide genetic, cellular and biochemical profiling of the cancer cell has greatly accelerated these advances. This pace will surely be accelerated exponentially in the future. The accumulation of new information is both impressive and daunting. Therefore, a major challenge of the next decade will be to translate basic cancer research advances into new molecularly targeted cancer therapies. The premise of the Cancer Cell Biology Training Program (CCBTP) is that cancer biology is a unique, interdisciplinary biomedical science that encompasses experimental approaches and didactic knowledge from cell biology, molecular biology, biochemistry, genetics, immunology, microbiology, pharmacology, epidemiology, toxicology, pathology, and physiology. Doctoral students will become well-trained in the paradigms of molecular and cellular biology from more traditional department- or curriculum-based training programs. Rarely will they receive significant training in the pathobiology and treatment of cancer. With an increasing emphasis on multidisciplinary, translational, disease-oriented research, the need to address this deficiency in graduate student training has become of greater urgency. Thus, the broad goal of this program is to provide comprehensive training in translational cancer biology to allow students to effectively contribute to the new wave of translational research. The CCBTP provides a strong emphasis on the histopathology of cancer and exposure to other topics crucial to tumor biology, in particular personalized medicine and molecularly targeted anti-cancer drug discovery and development. Therefore, it fosters the training of doctoral candidates who are uniquely trained and who are clearly distinguished from those of individual departments or other training programs funded by the National Institutes of Health at the University of North Carolina at Chapel Hill