Privileged Metallocene Catalysts for Asymmetric Synthesis

大块的钴金属茂物最近被发现应用于一些具有高对映选择性的不对称转化。由于缺乏合成平面手性衍生物的一般方法，这一领域的进一步发展受到阻碍。提出了一种解决该问题的一般方法，包括通过金属催化交叉偶联和/或对映选择性卤素-金属交换进行不对称脱对称。所得非外消旋产物将用于合成具有代表性的P、PN和PP配体，也可用于制备钯基和“有机催化”重排催化剂，用于不对称合成。

Bulky cobalt metallocenes have recently found application in a number of asymmetric transformations characterised by high enantioselectivity. The further development of this area is hampered by the absence of a general methodology for the synthesis of planar chiral derivatives. A general solution to this problem is proposed involving asymmetric desymmetrisation by either metal catalysed cross-coupling and/or enantioselective halogen-metal exchange. The resulting non-racemic products will be used for the synthesis of representative P, PN and PP ligands, and also for the generation of palladium based and 'organocatalytic' rearrangement catalysts for application in asymmetric synthesis.