400 MHz NMR Spectrometer for CSU Chemistry Facility

描述(由申请人提供)：科罗拉多州立大学化学系正在申请资金购买一台新的400 MHz核磁共振光谱仪，以取代我们已有10年历史的300 mhz核磁共振。该仪器将在该部的中央仪器设施(CIF)内进行管理。目前，我们的核磁共振工作的最大部分是在三个大量使用的仪器上进行的，其中一个--这项提议的主题--已经过了它的鼎盛时期。该仪器用于常规核磁共振研究的步进式模式。此时需要新的400核磁共振来取代老化和技术有限的300核磁共振。与它所替代的300核磁共振相比，它提供了更好的灵敏度、分辨率和性能。事实上，核磁共振性能足够好，我们预计将在这一新的400核磁共振上进行某些类型的核磁共振，例如C和FAST 2D，而不是像我们目前所做的那样，在CIF中更强大的13台仪器上进行。最后，主动屏蔽磁体提供了更小的总体系统占用空间，并将使我们能够更好地利用宝贵的实验室空间。所要求的400 MHz核磁共振光谱仪为NIH资助的项目提供分析支持，这些项目发现了高效和高纯度生产重要药用材料的新合成策略。该仪器还支持NIH资助的项目，这些项目发现了新的天然产品，这些产品可能是未来治疗包括结核病和麻风病在内的一些世界上最严重疾病的特效药。

DESCRIPTION (provided by applicant): The Chemistry Department at Colorado State University is requesting funds to purchase a new 400 MHz NMR spectrometer that will replace our ten year old 300 NMR. The instrument will be managed within the Department's Central Instrumentation Facility (CIF). At the present time, we do the greatest portion of our NMR work on three heavily used instruments, one of which - the subject of this proposal - is well past its prime. This instrument is used for routine NMR studies in a walk-up mode. The new, 400 NMR is needed at this time to replace the aging and technically limited 300 NMR. It offers significantly better sensitivity, resolution and performance compared with the 300 NMR that it replaces. Indeed, the NMR performance is sufficiently good that we expect to do some kinds of NMR, e.g. C and fast 2D, on this new 400 NMR rather than on the more powerful 13 instruments in the CIF as we do at present. Finally, the actively shielded magnet provides for a much smaller overall system footprint and will allow us to make better use of valuable laboratory space. The 400 MHz NMR spectrometer requested provides analytical support to NIH funded projects that discover new synthetic strategies for producing pharmacologically important drug materials efficiently and in high purity. The instrument also supports NIH funded projects that discover new natural products that may be tomorrow's wonder drugs for some of the world's worst diseases including tuberculosis and leprosy.