Extending and enhancing an fMRI power analysis tool.

描述（由申请人提供）：本研究旨在开发一种强大、灵活的功率计算工具，用于规划群功能磁共振成像（FMRI）研究。这将需要扩展FMRIPower的当前版本，FMRIPower是一个正在开发的软件工具，目前在NITRC数据库中列出。功率计算需要先前分析的结果，但灵活的功率分析模型增加了以最低成本找到强大的研究设计的能力。当前版本的FMRIPower只允许从FMRIB软件库（FSL）输入，并且只允许用户改变研究中受试者的数量。通过结合我们之前开发的方法，我们将使FMRIPower可用于更广泛的软件包，包括统计参数映射（SPM）和功能神经图像分析（AFNI）软件包，我们将扩展功率模型，以允许受试者数量的波动，以及每个受试者的运行次数和每次运行发生的刺激事件的数量。国家核研究委员会网站将有助于分发和评估FMRIPower。由于功率分析有助于确保收集到适当的样本量，因此所得到的工具将成为规划未来功能磁共振成像研究的资产，这将导致更好和更具成本效益的研究资金利用。公共健康相关性：拟议的研究旨在通过提供在群体功能磁共振成像中进行灵活的功率计算的手段来改善公共健康，以计划具有足够高的功率的研究设计，以检测效果，如果它存在，同时保持在拟议的预算范围内。目前缺乏灵活的软件来计算群体功能磁共振成像研究的功率，常常导致研究人员放弃功率计算或基于不相关研究的功率的基本样本量，导致研究功率过低而无法检测效果或成本过高的研究。我们免费提供的软件工具的开发将允许许多不同fMRI软件包的用户进行功率分析，并能够对研究设计进行许多调整，以最大化功率和最小化成本。

DESCRIPTION (provided by applicant): The proposed research aims to develop a powerful, flexible power calculation tool to be used for planning group functional magnetic resonance imaging (FMRI) studies. This will require extending the current version of FMRIPower, a software tool under development that is currently listed in the NITRC database. A power calculation requires results from a previous analysis, but flexible models for power analysis increase the ability to find a powerful study design that can be carried out for the lowest cost. The current version of FMRIPower only allows input from the FMRIB Software Library (FSL) and only allows users to alter the number of subjects in the study. By incorporating methods that we have previously developed, we will make FMRIPower accessible to a wider variety of software packages, including the Statistical Parametric Mapping (SPM) and Analysis of Functional NeuroImages (AFNI) packages, and we will extend the power model to allow fluctuations in the number of subjects as well as the number of runs per subject and the number of stimulus events that occur per run. The NITRC website will be helpful in distributing and assessing FMRIPower. The resulting tool will be an asset for the planning of future fMRI studies that will result in better and more cost- effective utilization of research funds, since power analyses help insure the appropriate sample size is collected. PUBLIC HEALTH RELEVANCE: The proposed research aims to improve public health by supplying the means to carry out a flexible power calculation in group fMRI to plan study designs with high enough power to detect an effect, if it is present, while staying within the proposed budget. The current lack of flexible software for calculating power for group fMRI studies often leads investigators to forego power calculation or base sample sizes on power from unrelated studies, leading to studies that are too underpowered to detect an effect or costly overpowered studies. The development of our freely available software tool will allow users of many different fMRI software packages to carry out power analyses with capabilities to make many adjustments to the study design in order to maximize power and minimize cost.