Transcriptional Activation by Reorganizing Chromatin

描述（由申请人提供）：SWI/SNF是第一个被鉴定的ATP依赖性染色质重塑复合物，从那时起，已经鉴定了无数不同的ATP重塑复合物，它们在细胞中具有不同的功能作用。所有真核生物都具有SWI/SNF，并且在人类中，SWI/SNF已被证明参与细胞发育、分化和细胞周期控制的许多方面。异常SWI/SNF已被证明与癌症及其发作有关。虽然SWI/SNF与核小体的相互作用的某些方面以及它重塑核小体的方式是已知的，但仍然有很多尚未很好地理解。我们建议通过进一步研究SWI/SNF与核小体的相互作用，SWI/SNF重塑的机制以及组蛋白修饰和辅助蛋白对SWI/SNF重塑的影响来扩展早期的研究。

DESCRIPTION (provided by applicant): SWI/SNF was the first ATP-dependent chromatin remodeling complex to be identified and since then a myriad of different ATP-remodeling complexes have been identified with varying functional roles in the cell. All eukaryotes possess SWI/SNF and in humans SWI/SNF has been shown to be involved in many aspects of cell development, differentiation and cell cycle control. Aberrant SWI/SNF has been shown to be linked to cancer and its onset. Although some aspects of the interactions of SWI/SNF with nucleosomes and the manner in which it remodels nucleosomes is known there is still much that is not well understood. We propose to extend earlier studies by further examination of the interactions of SWI/SNF with nucleosomes, the mechanism of SWI/SNF remodeling, and the effects of histone modifications and auxiliary proteins on SWI/SNF remodeling.