Tissue and Pathology Resources

人体组织样本的病理分析和分子表征是一项基本的和 孢子应用的所有部分的整体要求，包括系统的病理评估 微转移疾病、肿瘤基因组和基因的人体组织样本的采集和分析 基因工程小鼠肿瘤的发现，与分子成像相关的评价， 肿瘤信号通路的分析和肿瘤异质性的表征 化疗耐药。核心与五大项目中的每一个都高度整合。我们将密切合作 为三个具体目的与项目调查人员合作：i)提供组织标本； 病理学中的组织学服务和标准化的系统形态咨询专家 评估人类胃肠道肿瘤；ii)提供基础设施和技术专长 各种分子病理学检测，包括高效筛选和验证基因组和 人胃肠道组织标本中的蛋白质组学靶点；以及iii)评估和实施新的细胞 成像和分析技术将极大地促进未来的这些研究目标。集中化 这些核心活动建立在调查人员的既定基础设施和智力专长的基础上， 并为分析由 项目调查员。此外，核心与生物统计核心和基因组学有很强的整合 数据和生物信息学核心(核心3和4)，从而最大限度地利用这些 资源，并提供了大量机会，以显著提高对 胃肠道癌变。 我们的具体目标如下：(1)提供组织标本、组织学加工服务和 人胃肠道肿瘤的病理分析；(2)人胃肠道的特征 使用分子病理学工具治疗肿瘤；(3)评估和实施细胞新技术 成像和分子表征。

The pathologic analysis and molecular characterization of human tissue samples is a fundamental and integral requirement for all portions of this SPORE application, including systematic pathologic evaluation of micrometastatic disease, collection and analysis of human tissue samples for oncogenomics and gene discovery, evaluation of genetically engineered mouse neoplasms with moleclular imaging correlates, analysis of cancer signaling pathways, and characterization of tumoral heterogeneity in the emergence of chemoresistance. The core is highly integrated with each of the 5 major projects. We will work in close collaboration with the Project Investigators for three specific purposes: i) to provide tissue specimens, histology services and standardized systematic morphologic consultative expertise in the pathologic evaluation of human gastrointestinal neoplasms; ii) to provide infrastructure and technical expertise for a variety of molecular pathologic assays, including high-efficiency screening and validation of genomic and proteomic targets in human gastrointestinal tissue specimens; and iii) to evaluate and implement new cellular imaging and analysis technologies that will greatly facilitate these research goals in future. Centralization of these Core activities builds upon the established infrastructure and intellectual expertise of the investigators, and provides a highly valuable component to the analysis of biological resources developed and utilized by project investigators. In addition, the core has strong integrations with the Biostatistics Core and Genomic Data and Bioinformatics Cores (Cores 3 and 4), thereby leveraging the greatest benefits from these resources, and providing a wealth of opportunities for significant advances in understanding of gastrointestinal carcinogenesis. Our specific aims are as follows: (1) to provide tissue specimens, histologic processing services and pathologic analysis of human gastrointstinal neoplasms; (2) to characterize human gastrointestinal neoplasms using molecular pathology tools; (3) evaluate and implement new technologies for cellular imaging and molecular characterization.