BMC--BHASIN

波士顿医疗中心，波士顿，马萨诸塞州(BMC) 沙兰德·巴辛 老年人的功能衰退和依赖预示着不良的结局，并造成巨大的负担 关于医疗保健服务和成本。因此，功能促进合成代谢疗法(FPATs)可以改善 物理功能和减少功能限制的负担是可取的。波士顿克劳德 A.胡椒老年美国人独立中心(OAIC)，其主题集中在功能限制和 FATS将把NIH资助的13项研究、4个创新试点项目和2个开发项目整合为一个 由领导和行政核心支持的具有凝聚力的跨学科项目，一项研究 职业发展核心(RCDC)，一个试点和探索性研究SxCore，以及三个资源核心 (功能评估核心、肌肉祖细胞核心和系统生物学核心)。波士顿OAIC是 其在整个翻译发现研究领域的独特定位：13个OAIC项目， 试点和发展项目将阐明功能受限的流行病学和 FPAT作用机制，有助于确定FPAT发现的靶点和FPAT作用的生物标志物；以及 促进领先的抗癌药物的方法开发、结果验证和疗效试验。RCDC将 从几个学科中招募最好的候选人，包括老年学和老年学，并对他们进行培训 通过有组织的说教教育和有指导的研究计划。跨OAIC的集成将是 通过每周跨学科研究会议、一年两次的务虚会、一个网站、共同主题来实现 重点，以及旨在促进合作的促进方案。社区外展和 OAIC活动的传播将通过大使方案实现，该方案将组织 社区活动、时事通讯和社区咨询委员会。OAIC的独特优势包括 专注于FPAT，强调创新，其扩展到整个翻译研究范围，从 功效试验的机制阐明，其成员之间富有成效的合作历史，强大 基础设施和机构承诺，并纳入几项重要的流行病学调查 (FHS、MMAS、BACH、百岁老人研究和BOKS)、FPAT干预试验和基于机制的FPAT 发现。波士顿OALC的协作战略应该有助于加快研究成果的翻译 转化为基于证据的FPAT，并培养新一代老龄化研究人员。

Boston Medical Center, Boston, Massachusetts (BMC) Bhasin, Shalender Functional decline and dependence in older individuals portend poor outcome, and impose a large burden on health care services and costs. Therefore, function promoting anabolic therapies (FPATs) that improve physical function and reduce the burden of disabling functional limitations are desirable. The Boston Claude A. Pepper Older Americans Independence Center (OAIC) with its thematic focus on functional limitations and FPATs will integrate 13 NIH-funded studies, 4 innovative pilot projects, and 2 developmental projects into a cohesive interdisciplinary program that is supported by a Leadership and Administrative Core, a Research Career Development Core (RCDC), a Pilot and Exploratory StudieSxCore, and three resource cores (Function Assessment Core, Muscle Progenitor Cell Core, and Systems Biology Core). The Boston OAIC is unique in its positioning across the entire spectrum of translational discovery research: 13 OAIC projects, and pilot and developmental projects will elucidate the epidemiology of functional limitations and mechanisms of FPAT action, help identify targets for FPAT discovery and biomarkers of FPAT action, and facilitate methods development, outcomes validation, and efficacy trials of leading FPATs. The RCDC will recruit the best candidates from several disciplines, induing Geriatrics and Gerontology, and train them through a structured didactic education and mentored research program. Integration across OAIC will be achieved by weekly interdisciplinary research meetings, biannual retreats, a website, common thematic focus, and the PROMOTE program aimed at promoting collaboration. Community outreach and dissemination of OAIC activities will be achieved through Ambassador's Program which will organize community events, a newsletter, and a Community Advisory Board. Unique strengths of OAIC include its focus on FPATs, emphasis on innovation, its extension across entire spectrum of translational research from mechanism elucidation to efficacy trials, a history of productive collaborations among its members, strong infrastructure and institutional commitment, and inclusion of several important epidemiologic investigations (FHS, MMAS, BACH, Centenarian Study, and BOKS), FPAT intervention trials, and mechanism-based FPAT discoveries. Boston OAlC's collaborative strategies should help expedite the translation of research results into evidence-based FPATs and nurture a new generation of aging researchers.