Translational Research Core

翻译研究核心旨在促进和促进人体皮肤主题研究 生物学和皮肤病。第一个目标是提供具有成本效益的中央资源，以确定和招聘 志愿者参与人体活体研究和/或捐献血液或皮肤活检组织用于体外/体外 调查。核心执行程序，如皮肤暴露于模拟太阳辐射，半抗原 敏化和激发，非侵入性监测(例如，超声波、比色法、经皮 失水测量)和组织采集(静脉穿刺术、穿孔术和角膜切割术)。使用率 这些功能的扩展主要是通过与转介患者的医生和 其他调查人员通过病例综合癌症中心，综合临床研究中心， 艾滋病研究中心，以及大学内的其他研究中心。一名研究助理坐标 这些服务。第二个目标是提供对带来的新疗法的临床试验的全面管理 从实验室到床边，重点是提供最佳的翻译和临床数据。一个 在一般试验设计以及数据和安全监测方面具有专业知识的团队将有效地整合在一起 指导或进行高质量的研究，这些研究是通过与各种感兴趣的研究人员互动而产生的 皮肤研究。此外，还促进了临床和实验室研究人员之间的互动，以插入 辅助实验室研究，以阐明治疗的作用机制和疾病的病理机制。 第三个目标是促进青年研究人员和初级教员在人权领域的职业发展。 基于主题的皮肤研究。这涉及在多个级别上提供支持(例如，IRB提交、协议 设计、数据分析、手稿准备)取决于调查人员的需要。

The Translational Research Core is designed to promote and facilitate human subject research in skin biology and skin disease. The first aim is to provide a cost-efficient, central resource to identify and recruit volunteers to participate in human in vivo studies and/or donate blood or skin biopsy tissue for ex vivo/in vitro investigations. The Core performs procedures such as skin exposure to simulated solar radiation, hapten sensitization & elicitation, non-invasive monitoring (e.g., ultrasonography, chromometry, transepidermal water loss measurement) and tissue acquisition (venipuncture, punch & keratome biopsies). The utilization of these functions are expanded mainly by active interactions with physicians who refer patients and with other investigators through the Case Comprehensive Cancer Center, the General Clinical Research Center, Center for Aids Research, and other research foci within the University. A research assistant coordinates these services. The second aim is to provide overall management of clinical trials of novel therapies brought from the laboratory to the bedside with emphasis on providing optimal translational and clinical data. A group with expertise in general trial design as well as data and safety monitoring are assembled to efficiently direct or conduct high quality studies that arise through interaction with various investigators interested in skin research. Additionally, interactions between clinical and laboratory researchers are fostered to insert adjunctive laboratory studies to clarify mechanisms of action of therapies and pathomechanisms of disease. The third aim is to foster career development of young investigators and junior faculty in the area of human subject-based skin research. This involves providing support at multiple levels (e.g. IRB submission, protocol design, data analysis, manuscript preparation) depending on investigator needs.