Development Core

CFAR发展核心的目的是促进与艾滋病毒/艾滋病有关的 贝勒和UTHOUSTON的研究，这是通过几种方式完成的，其中两种是新的， 重新提交第一，支持由研究人员发起的科学研究，以开发初步数据， 研究应用。符合条件的项目类型包括试点和可行性研究以及合作项目。 翻译研究项目。第二，一项新的努力，称为“合作核心倡议”，目标是 具体的研究差距和机会在我们的CFAR。第三，也是新的，有一些资金是专门支持的 利用我们CFAR的优势，机会和专业知识制定科学计划。 我们选择首先强调“艾滋病毒和合并感染”，重点是结核分枝杆菌。 奖项是在严格的同行评审制度下颁发的。资金也可用于协助招聘 从事艾滋病毒/艾滋病研究的新教师。最后，对于这个应用程序，我们将提供一个 全面的指导计划，以帮助初级调查员的职业发展， 艾滋病毒/艾滋病研究。 这个核心有一个令人印象深刻的记录，从前贝勒CFAR的成就。从1995年到 2001年，发展奖（646，005美元）资助了33个基础和临床研究项目。 在33名获奖者中，有21人在3年内获得了总额超过1240万美元的外部资助 在他们获奖后，成功率达到63%，CFAR投资资金杠杆率达到19倍。 在3年的随访期间，受赠者发表了190多篇文章。发展基金还 被用来协助招聘两名初级教员。我们要求每年22万美元， 11-15年继续这些发展努力。发展基金在各部门之间的分配 每年的发展计划将由CFAR内部咨询委员会决定。核心 由Janet Butel博士（主任）和两位副主任玛丽埃斯蒂斯博士（贝勒）和玛丽博士领导 Velasquez（UTHOUSTON）.贝拉斯克斯医生是新任命的。

The purpose of the CFAR Developmental Core is to foster the development of HIV/AIDS-related research at Baylor and UTHouston, This is accomplished in several ways, two of which are new to this resubmission. First, investigator-initiated scientific studies are supported to develop preliminary data for research applications. Types of eligible projects include pilot and feasibility studies and collaborative translational research projects. Second, a new effort, designated "Collaborative Core Initiatives", targets specific research gaps and opportunities at our CFAR. Third, also new, some funds are dedicated to support the development of Scientific Programs that draw on strengths, opportunities, and expertise at our CFAR. We have chosen to emphasize first "HIV and Coinfections", focusing on Mycobacterium tuberculosis. Awards are made following a rigorous peer review system. Funds also may be used to assist in recruitment of new faculty engaged in HIV/AIDS research. Finally, new to this application, we will provide a comprehensive mentoring program to help the career development of junior investigators involved in HIV/AIDS research. This core has an impressive record of accomplishments from the former Baylor CFAR. From 1995 to 2001, Developmental awards ($646,005) supported 33 projects on both basic and clinical research topics. Twenty-one of the 33 awardees obtained external funding totaling over $12.4 million within 3 years following their award, representing a success rate of 63% and a 19-fold leveraging of CFAR funds invested. Grantees published over 190 articles during the 3-year follow-up period. Developmental funds have also been used to assist in the recruitment of two junior faculty members. We are requesting $220,000/year in Years 11-15 to continue these developmental efforts. Allocations of Developmental funds among the various developmental programs each year will be determined by the CFAR Internal Advisory Committee. The Core is led by Dr. Janet Butel, Director, and two Associate Directors, Drs. Mary Estes (Baylor) and Mary Velasquez (UTHouston). Dr. Velasquez is a new appointment with this resubmission.