Administrative Core

行政核心

• 批准号: 7683336
• 负责人: JANET S BUTEL
• 金额: $ 58.72万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7683336
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Advisory Committees; Area; Behavioral; Behavioral Sciences; Clinical; Clinical Research; Collaborations; Communication; Consult; Critiques; Development; Evaluation; Faculty; Fostering; Funding; Future; Goals; Grant; HIV; Hand; Health Services Research; Human Resources; Immunology; Information Dissemination; Institution; International; Leadership; Left; Maintenance; Medicine; Mentors; Modification; Mycobacterium tuberculosis; Occupational activity of managing finances; Policies; Preparation; Procedures; Process; Program Development; Published Comment; Purpose; Records; Regrets; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Role; Services; Strategic Planning; Texas; Thinking; Translational Research; United States National Institutes of Health; Universities; Vision; career; college; design; human subject; improved; innovation; member; programs; response; virology

The leadership of the Baylor-UTHouston Center for AIDS Research thanks the reviewers for their thoughtful comments in the previous critique. Those comments were very helpful and guided our strategic thinking as we planned and prepared this revised application. We also consulted with NIH CFAR program officials and obtained advice from our External Advisors as part of the resubmission process. Some of the criticisms in the critique reflected inadvertant omissions of certain details as well as inadequate presentations of past accomplishments or future plans. We have responded to those criticisms throughout this revised application by expanding the narrative and providing more detailed descriptions and specific examples of activities and services and of research and educational programs. We regret the omission and inadequate descriptions of Protection of Human Subjects information in some of the Cores and it has been corrected in this resubmission. There were more substantive concerns expressed about the organization or value of certain cores. To respond to those criticisms, we carried out a complete re-evaluation of our strengths, weaknesses and opportunities and analyzed the role of each core in facilitating AIDS-related translational research. Several cores were reorganized and major modifications made in their goals and/or services and functions (Clinical Research, Behavioral Science, and International Research). The other scientific cores (Immunology, Virology, Design and Analysis) were also revised. Questions about lack of innovation prompted us to formulate a strategy involving a more proactive use of Developmental funds to foster translational research in areas of gaps and opportunity at our CFAR that would take advantage of our strengths and promote synergy among the cores. Two applications of this type were funded in the most recent Developmental grants cycle, both of which involved collaborations between Baylor and UTHouston researchers. We also formalized a plan to support the development of a broad Scientific Program in HIV and Coinfections, focusing on HIV and Mycobacterium tuberculosis. Diagrams illustrating these new collaborative projects are included in various Core descriptions. In addition, we designed a comprehensive mentoring plan to help the career development of junior investigators in HIV/AIDS research. These new plans are presented in the Developmental Core and referenced throughout the application. There were questions raised about the new partnership between Baylor College of Medicine and the University of Texas-Houston. We acknowledge that aspects of that relationship were ill-defined in the previous application. In the intervening year between that first application and this resubmission, substantial progress has been made in integrating CFAR activities and management at the two institutions. This improved integration will be evident throughout this revised application. Examples of this integration include addition of UTHouston faculty members to the leadership of several cores and to Core Oversight Committees, successful competition by UTHouston CFAR members for 2004 Developmental funds, and the development of new research collaborations between Baylor and UTHouston faculty. Importantly, leaders of ADDS research at the two institutions share a common vision of the CFAR and its benefits. We are energized by the plans for a more proactive CFAR and the expanded opportunities for translational HIV/AIDS research that emerged during this revision process. Responses to specific comments in the critique are presented at the beginning of each core. Unless noted otherwise, changes in this revised application are marked with a vertical line in the left-hand margin.

贝勒-德克萨斯大学休斯顿艾滋病研究中心的领导感谢审查员们 在上一篇评论中发表了深思熟虑的评论。这些评论非常有帮助，并指导了我们的战略 在我们计划和准备这份修订后的申请时进行了思考。我们还咨询了NIH CFAR项目 作为重新提交程序的一部分，我们还从外部顾问那里获得了咨询意见。 批评中的一些批评反映了对某些细节的无意遗漏以及不足 展示过去的成就或未来的计划。我们在整个过程中都对这些批评做出了回应 通过扩展叙述并提供更详细的描述和具体实例来修订应用程序 活动和服务以及研究和教育方案。我们对遗漏和不足深表歉意。 一些核心中关于保护人类主体信息的描述，并已在此更正 重新提交。 对某些核心的组织或价值表示了更多的实质性关切。至 作为对这些批评的回应，我们对我们的优势、劣势和 并分析了每个核心在促进与艾滋病有关的转化研究方面的作用。几个 对核心进行了重组，并对其目标和/或服务和功能进行了重大修改(临床 研究、行为科学和国际研究)。其他科学核心(免疫学、病毒学、 设计和分析)也进行了修订。 关于缺乏创新的问题促使我们制定了一项战略，涉及更积极地使用 发展基金，在我们的CFAR的差距和机会领域促进翻译研究，这将 发挥优势，促进核心协同。这类应用程序有两个 在最近的发展赠款周期中提供资金，这两个周期都涉及贝勒之间的合作 德克萨斯大学休斯顿分校的研究人员。我们还正式制定了一项计划，以支持发展广泛的科学 艾滋病毒和混合感染方案，重点关注艾滋病毒和结核分枝杆菌。插图说明 这些新的协作项目包含在各种核心描述中。此外，我们还设计了一个 全面的指导计划，以帮助艾滋病毒/艾滋病研究方面的初级调查人员的职业发展。 这些新计划在开发核心中提出，并在整个申请过程中被引用。 有人对贝勒医学院和 德克萨斯大学休斯顿分校。我们承认，这种关系的各个方面在过去的 申请。在第一次申请和这次重新提交之间一年中，取得了实质性进展 在整合CFAR活动和两个机构的管理方面取得了进展。这一点改进了 在这一修订的应用程序中，整合将是显而易见的。此集成的示例包括添加 UT休斯顿教职员工到几个核心的领导和核心监督委员会，成功 休斯顿大学CFAR成员对2004年发展基金的竞争和新的发展 贝勒和休斯顿大学教职员工之间的研究合作。重要的是，ADS研究的领导人在 两家机构对CFAR及其好处有着共同的愿景。我们被更多的 积极主动的CFAR和在此期间出现的翻译艾滋病毒/艾滋病研究的更多机会 修订过程。 对评论中具体评论的答复列在每个核心的开头。除非注明，否则 否则，此修订后的应用程序中的更改将在左侧页边空白处用竖线标记。