Morphology Core

形态学核心的主要目标是提高新手的多功能性和生产力， 皮肤研究人员（P & F资助的科学家）和建立皮肤研究人员， 皮肤样本的显微镜分析技术。我们将继续实现这些目标 通过充当成功/不成功的免疫组织化学染色方案的储存库， 抗血清，通过筛选和优化免疫组织化学染色的新抗血清， 并通过协助研究人员解释，因为他们试图定义皮肤异常和反应。到 实现这些目标，核心将提供最先进的包埋，切片（冷冻或石蜡）， 由经过培训的专家进行及时和低成本的染色（主要是免疫组织化学染色）。的 主任和核心人员将提供教学援助和建议，在显微镜技术有用的皮肤 分析范围广泛的个人，包括P & F研究人员，资助SDRCC研究人员，以及他们的博士后 研究员、研究生、学生和实验室人员。Morphology Core将继续提供 开拓/培育环境，最初尝试尖端免疫组织化学技术， 在经验丰富的团队指导下完成。核心还将继续推出新的试剂 和技术进步，表现出更大的敏感性。我们将继续努力， 使用途径特异性免疫探针的方案。核心将密切合作，帮助调查人员定制 适用于组织微阵列的标准化免疫标记物组。合作互动 其他的SDRCC核心将很容易发生。由于这个核心是范德比尔特的制度核心系统的一部分， 与其他相关核心（如人体组织和病理学共享）建立了良好的联系 资源，分子识别（抗血清生产）核心，小动物成像核心，电子 显微镜核心，蛋白质组学核心或细胞成像/共聚焦核心。

The primary objective of the Morphology Core is to enhance the versatility and productivity for both novice cutaneous investigators (P & F funded scientists) and established skin investigators by facilitating access to techniques directed toward the microscopic analysis of skin samples. We will continue to accomplish these goals by serving as a repository of successful/unsuccessful immunohistochemical staining protocols with proven skinspecific antisera, by providing screening and optimization of new antisera for immunohistochemical staining, and by assisting investigators with interpretation as they seek to define skin abnormalities and responses. To achieve these objectives, the Core will render state-of-the-art embedding, sectioning (frozens or paraffins), and staining (primarily immunohistochemical staining) in a timely and low-cost basis by trained experts. The Director and Core personnel will supply teaching assistance and advice in microscopic techniques useful for skin analysis for a wide range of individuals including P & F investigators, funded SDRCC investigators, and their postdoctoral fellows, graduate, students, and laboratory personnel. The Morphology Core will continue to provide a pioneering/nurturing environment where cutting edge immunohistochemical techniques are initially tried and achieved under the guidance of an experienced team. The Core will also continue to introduce of new reagents and technological advancements that exhibit greater sensitivities. We will continue to generate working protocols with pathway specific immunoprobes. The Core will work closely to help investigators customize panels of standardized immunomarkers suitable for use in tissue microarrays. Cooperative interactions among the other SDRCC Cores will occur with ease. Since this Core is a portion of Vanderbilt's Institutional Core system, liaisons are well established with other relevant Cores such as the Human Tissue and Pathology Shared Resource, Molecular Recognition (Antisera Production) Core, Small Animal Imaging Core, the Electron Microscopy Core, Proteomics Core or Cell Imaging/Confocal Core.