Shock Center for Aging Research at The Jackson Laborato*

描述（由申请人提供）：为了识别基因并探索调节人类衰老和对年龄相关疾病易感性的分子途径，具有良好特征和遗传定义的小鼠提供了选择模型系统。杰克逊实验室拥有丰富的近亲繁殖和突变小鼠品种，在小鼠饲养方面的专业知识，以及在小鼠生物学方面的多样性专业知识，因为它适用于衰老。在杰克逊实验室建立一个卓越的衰老生物学Nathan Shock中心，将支持这里已经很重要的与年龄相关的研究水平，并通过研究发展核心，吸引现有的研究人员和新招募的人员来探索他们自己的研究项目与衰老相关问题的关系。此外，由于杰克逊实验室是信息和独特小鼠品系的国际资源，这里的内森电击中心的贡献将在全国范围内发挥作用。来自单个中心成员研究群体的小鼠将在分散的动物核心中老化，这将向其他中心成员和外部科学家开放大量与衰老相关的遗传资源。Phenome Core将提供一种全新的预测定量性状分析能力，通过描述一组常用的、基因多样化的小鼠品系的衰老参数，并在公开可用的小鼠表型数据库中管理详细的基因组序列和制图数据，从而加速衰老生物学的遗传分析。该中心还将支持增强体内成像、生理测量和显微镜的能力，通过表型核心来评估衰老的表型。计算核心将为统计遗传学分析和工作流管理工具提供支持。总之，杰克逊实验室的内森休克中心将为国际社会提供更多的资源，并更好地了解衰老及其相关疾病的分子机制。

DESCRIPTION (provided by applicant): To identify genes and explore molecular pathways that regulate aging and susceptibility to age-related disorders in humans, well-characterized and genetically defined mice offer a choice model system. The Jackson Laboratory has a wealth of inbred and mutant strains of mice, expertise in mouse husbandry, and diversity of expertise in the biology of the mouse as it applies to aging. Establishing a Nathan Shock Center for Excellence in the Biology of Aging at The Jackson Laboratory will support an already significant level of age-related research here and, through a Research Development Core, attract both established investigators and new recruits to explore the relationship of their own research programs with questions pertinent to aging. Moreover, because The Jackson Laboratory is an international resource for information and unique strains of mice, the contribution of a Nathan Shock Center here will be leveraged nationally. Mice from individual Center members' research colonies will be aged in a dispersed Animal Core, that will open an enormous variety of genetic resources relevant to aging to other Center members and external scientists. The Phenome Core will offer an entirely new capability for predictive quantitative trait analysis to accelerate genetic analysis of the biology of aging, by characterizing parameters of aging for a set of commonly used, genetically diverse strains of mice and curating the data with detailed genomic sequence and mapping data in the publicly available Mouse Phenome Database. The Center will also support enhanced capabilities for invivo imaging, physiological measurements, and microscopy to evaluate phenotypes of aging through a Phenotyping Core. The Computing Core will provide support for statistical genetics analysis and workflow management tools. In sum, the Nathan Shock Center at The Jackson Laboratory will lead to enhanced resources for the international community and better understanding of the molecular mechanisms at work in aging and its associated disorders.