NBTS Symposium: Fetal Behavior and Neurotoxicology

描述(由申请人提供)：此申请寻求资金支持6月29日在加利福尼亚州蒙特利举行的神经行为畸形学学会(NBTS)年会上举行的研讨会。NBTS与两个“姊妹”学会--畸胎学学会(TS)和畸胎学信息专家组织(OTIS)联合开会，其成员也将能够参加研讨会。 研讨会将介绍(1)在啮齿动物模型中胎儿行为以及从产前到出生后生命转变的神经和行为方面的研究进展；(2)这些进展如何服务于NBTS的使命，以确定和了解不利的神经行为发育的原因和机制，从而预防或治疗人类发育障碍；以及(3)如何在更广泛的表观遗传学框架内(如成人疾病的胎儿基础，FEBAD)理解发育神经毒性。研讨会的参与者-斯科特·罗宾逊、阿普丽尔·隆卡和盖尔·克莱文-是这些主题的领先专家，他们将向目前还不知道这一领域进展的畸形学家和发育神经毒理学家介绍他们的工作。 因此，研讨会将以一种及时、创新的方式对发育心理生物学和发育神经毒理学领域进行“交叉培养”，对基础科学和公共卫生的发展都具有重要意义。这次研讨会是及时的，因为这些方法最近出现了，而且在神经毒理学中还没有应用到许多问题上。它具有创新性，因为它可能揭示神经行为畸形学中只能在胎儿和围产期研究的新机制和干预措施。这对公共福利意义重大，因为人们越来越意识到发展和环境因素在精神分裂症、自闭症、多动症和帕金森症等精神和神经疾病中所起的作用。最后，这次研讨会将以一种可能促进创新和新合作的方式弥合不同研究人员和从业人员社区之间的差距。一篇总结研讨会的文章将被邀请在《神经毒理学和畸形学》杂志上发表，供同行评议发表。

DESCRIPTION (provided by applicant): This application seeks funding to support a symposium to be held on June 29th at the annual meeting of the Neurobehavioral Teratology Society (NBTS) in Monterey, CA. NBTS meets jointly with two "sister" societies, the Teratology Society (TS) and the Organization of Teratology Information Specialists (OTIS), whose members will also be able to attend the symposium. The symposium will describe (1) recent advances in the study of fetal behavior and of neural and behavioral aspects of the transition from prenatal to postnatal life in rodent models; (2) how these advances can serve the mission of NBTS to identify and understand the causes and mechanisms of adverse neurobehavioral development so as to prevent or treat human developmental disorders; and (3) how developmental neurotoxicity can be understood within broader epigenetic frameworks (e.g., Fetal Basis of Adult Disease, FEBAD). The symposium participants - Scott Robinson, April Ronca, and Gale Kleven - are leading experts on these topics who will be presenting their work to an audience of teratologists and developmental neurotoxicologists who are presently not aware of advances in this field. The symposium would therefore "cross fertilize" the fields of developmental psychobiology and developmental neurotoxicology in manner that is timely, innovative, and highly significant to the advancement of both basic science and public health. The symposium is timely because of the recent emergence of these methods and the many problems in neurotoxicology to which they have yet to be applied. It is innovative because it is likely to reveal new mechanisms and interventions in neurobehavioral teratology that can only be studied during the fetal and perinatal periods. It is significant to public welfare because of the growing awareness of the role that developmental and environmental factors play in psychiatric and neurological disorders such as schizophrenia, autism, ADHD, and Parkinsonism. Finally, this symposium will bridge the gap among different communities of researchers and practitioners in a manner that is likely to foster innovative, new collaborations. An article summarizing the symposium will be invited for peer-reviewed publication in the journal Neurotoxicology and Teratology.