LSI DTCs 2007-Doctoral Training Centre for Regenerative Medicine

美国健康状况的持续改善有赖于可负担得起的替代人体组织和相关疗法的有效开发；自愿器官捐赠者的严重短缺和传统疗法的缺点每年导致许多患者可预防的死亡。下一次医疗革命将应用再生医学，创造生物疗法或替代品，以取代或恢复因失败或疾病而丧失的组织功能。然而，尽管科学已经揭示了这种疗法的潜力，早期的产品也展示了这种疗法的力量，但在人类医疗保健的预期好处得以实现之前，现在需要长期供应经过适当培训的人员，这些人具备必要的技能，以应对工程和生命科学的挑战。由于这种技术产生的产品与主流制药公司生产的产品有很大不同，现有的培训方案装备不足，无法满足越来越多的受过适当培训的人员的需求。我们估计，拥有与尖端生物科学家和临床医生“在同一层面上”互动的必要技能的工程师数量非常少，全国可能不超过100人；在这样一个小社区里，新培训的50名博士将产生非常大的影响。在这里，我们建议建立一个新的英国再生医学DTC，整合三所大学，具有高度互补性的专业知识，学生将接受在生命科学/工程接口工作所需的核心技能方面的培训，然后参与旨在应对该领域主要挑战的战略研究计划。这将确保为英国在这个快速增长的全球市场中处于领先地位开发必要的人员和使其能够使用的技术。

SummaryContinued improvement in the nation's health depends upon the efficient development of affordable replacement human tissue and related therapies; an acute shortage of willing organ donors and the shortcomings of conventional therapies leads to the preventable death of many patients each year. The next healthcare revolution will apply regenerative medicines, creating biological therapies or substitutes for the replacement or restoration of tissue function lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is now a need for the long term supply of people properly trained with the necessary skills to face the engineering and life science challenges before the predicted benefits in human healthcare can be realised. Because the products arising from this technology differ significantly from those made by mainstream pharmaceutical companies, training programmes currently available are poorly equipped to meet the demand for increasing numbers of appropriately trained personnel. We estimate that the number of engineers with the necessary skills to interact `on the same level' with cutting edge bioscientists and clinicians is very small, perhaps no more than 100 nationally; in such a small community 50 newly trained PhD's will have a very large impact. Here we propose a new UK based DTC in Regenerative Medicine integrated across three Universities with highly complementary expertise where students will be trained in the core skills needed to work at the life science/engineering interface and then engaged in strategic research programmes designed to address the major challenges in the field. This will ensure that the necessary people and enabling technologies are developed for the UK to lead in this rapidly growing worldwide marketplace.