CORE--BIOSTATISTICS AND DATA MANAGEMENT

拟议中的Conte精神障碍神经科学中心精神分裂症研究整合了临床，基础和统计科学家的努力，共同努力评估精神分裂症与多巴胺功能失衡相关的假设。生物统计学和数据管理核心（BDMC）是研究人员在研究过程的所有阶段寻求数据收集，研究设计，统计分析和分析解释的建议和技术支持的资源。中心研究人员将收集的数据来自广泛的来源。品种和 大量的数据代表着该中心的巨大潜力，但也强调了适当的数据管理和统计分析对实现该中心目标的重要性。 生物统计学资源在BDMC内的具体目标是：1）提供密集的， 协调对中心研究的设计、实施和分析的投入; 2）协助中心成员寻求独立的研究资金; 3）参与审查从中心数据库分析中得出的出版物/演示材料; 4）监督和协调统计人员和数据分析人员在提供日常分析支持方面的活动。 BDMC中数据管理资源的目标是：1）：作为中心管道，通过该管道整合来自不同核心和项目的数据; 2）维护和扩展中心现有的包含临床前、临床和脑成像数据的数据库; 3）为数据库规划和编程以及数据输入提供协调协助; 4）准备一份可导出的数据档案，以便分发给哥伦比亚/NYSPI内外的研究者。 一个专门用于生物统计和数据管理的核心将加强数据收集和分析过程，使所有共同研究者能够更充分地实现每个核心和项目提出的实质性研究目标。

The proposed Conte Center for the Neurosciences of Mental Disorders in Schizophrenia Research integrates the efforts of clinical, basic, and statistical scientists in a common effort to evaluate the hypothesis that schizophrenia is associated with an imbalance in dopamine functions. The Biostatistics and Data Management Core (BDMC) constitutes a resource for investigators seeking advice and technical support for data collection, study design, statistical analysis, and analytic interpretation at all stages of the research process. The data that will be collected by Center investigators come from a wide range of sources. The variety and volume of data represent enormous potential for the Center, but also underscore the importance of proper data management and statistical analysis to achieve the Center's aims. The specific aims for the Biostatistics Resource within the BDMC are: 1) To provide intensive, coordinated input into the design, conduct, and analysis of Center studies; 2) To assist Center members in the pursuit of independent research funding; 3) To participate in the review of publication/presentation materials that derive from analyses of the Center database; 4) To oversee and coordinate the activities of statisticians and data analysts in providing day-to- day support for analysis. The:aims of the Data Management Resource wiithin the BDMC are: 1):To serve as the central conduit through which the data from the various cores and projects are integrated; 2)To maintain and expand the Center's existing database containing pre-clinical, clinical, and brain imaging data; 3 ) To provide coordinated lassistance with database planning and programming and data entr;; 4) To prepare an exportable data archive suitable for distribution to investigators both within and outside of Columbia/NYSPI. A Core devoted to biostatistics and data management will enhance the process of data collection and analysis, allowing all co-investigators to be more fully productive in fulfilling the substantive research aims put forth by each Core and Project.