Identification and characterisation of genes causing Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE) and related phenotypes

癫痫影响了大约2%的人在他们生命的某个阶段。我们最近发现了两个新的基因，它们与一种被称为ADNFLE的癫痫的发生有关。我们的目标是通过对尚未发现突变的ADNFLE患者进行测序来识别更多的癫痫基因。我们的目标也是识别与我们已经识别的基因相互作用的基因，增加我们对癫痫发展过程中涉及的细胞网络的理解。

Epilepsy affects approximately 2% of the population at some stage of their lives. We have recently identified two new genes involved in the development of a type of epilepsy known as ADNFLE. We aim to identify further epilepsy genes by sequencing ADNFLE patients who do not yet have identified mutations. We also aim to identify the genes interacting with the genes we have identified, increasing our understanding of the cellular networks involved in the development of epilepsy.