Identification and characterisation of HLA-E restricted influenza A virus-specific CD8+ T cells
Identification and characterisation of HLA-E restricted influenza A virus-specific CD8+ T cells
批准号:
nhmrc : GNT1110429
负责人:
Dr Emma Grant
金额:
$35.42万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Early Career Fellowships
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 --
中文摘要
随着季节性流行病和大流行的持续威胁,迫切需要一种一次性通用疫苗,以防止不同的流感病毒株。这可以通过激活杀伤T细胞来实现。我将鉴定一种高度保守的人类蛋白质所呈现的新病毒靶点。杀伤T细胞对这些靶点的识别可能为开发改进的疫苗提供了独特的机会。
英文摘要
With seasonal epidemics and the continual threat of a pandemic, there is an urgent need for a one-shot universal vaccine that protects against different influenza strains. This can potentially be achieved by the activation of killer T cells. I will identify new virus targets presented by a highly conserved human protein. Killer T cell recognition of these targets may provide a unique opportunity to develop an improved vaccine.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
The investigation of an unconventional Human Leukocyte Antigen molecule
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批准号:DE210101479
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项目类别:Discovery Early Career Researcher Award
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资助金额:$31.72万
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财政年份:2021
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负责人:Dr Emma Grant
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依托单位:
Identification and characterisation of HLA-E restricted influenza A virus-specific CD8+ T cells
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批准号:nhmrc : 1110429
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项目类别:Early Career Fellowships
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资助金额:$24.47万
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财政年份:2016
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负责人:Dr Emma Grant
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依托单位:
Understanding influenza-specific T cell immunity in the Indigenous and non-Indigenous populations
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批准号:nhmrc : 1055323
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项目类别:Postgraduate Scholarships
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资助金额:$3.28万
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财政年份:2013
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负责人:Dr Emma Grant
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依托单位:
海外基金