Designed Peptide Gels for 3D Cell Culture

对生物材料的期望是巨大的，不仅对改进医疗设备和提高生活质量抱有很大希望，而且在使药物发现和制药开发合理化方面也抱有很大希望。我们最近专注于开发用于3D细胞培养的简单、廉价但具有功能的多肽材料，最终用于再生医学的长期应用。使用合理的设计来匹配一系列细胞类型的特定要求，我们已经能够将这些生物材料应用于体外三维(3D)细胞培养。拟议的项目将使我们能够消除用户差异，并在为体外细胞培养市场推出新的商业产品之前，与领先的学术和商业合作伙伴对这些凝胶进行独立评估试验。

Expectations for biomaterials are enormous, with great hope not only for improved medical devices and enhanced quality of life, but also in rationalising drug discovery and pharmaceutical development. We have recently focused on developing simple, cheap, yet functional peptide materials for 3D cell-culture, ultimately towards long-term applications in regenerative medicine. Using rational design to match specific requirements of a range of cell types, we have been able to apply these biomaterials in three dimensional (3D) cell culture in vitro. The proposed project will enable us to eliminate user variance and undertake independent evaluation trials of these gels with leading academic and commercial partners, prior to launch of a new commercial product for the in vitro cell culture market.