Taskforce for Obesity Research at Southwestern (TORS)

肥胖和相关代谢危险因素(致动脉粥样硬化性血脂异常、高血糖、 高血压、肝脏脂肪变性、血栓前状态和炎症状态)对死亡和 美国的残疾问题。导致肥胖和代谢综合征的机制有 拒绝通过传统方法进行澄清。该领域的专家提出了这一进展 为了了解导致肥胖的基因/环境相互作用，将需要实施 基础广泛的临床和基础研究计划。为了开发这样一个程序，我们已经组装了一个高度 德克萨斯大学西南分校互动和协作的跨学科专家团队称为 西南肥胖研究(TORS)。TORS利用高度不同学科的专业知识， 定义导致肥胖的行为、代谢、遗传和分子机制的目标 代谢综合征。我们在过去两年的P20资助中取得的成就表明，我们已经 成功地整合了解剖学、生物化学、化学、遗传学、脂类等传统上截然不同的学科 代谢、分子生物学、中间代谢、神经内分泌学、营养学、药理学 将生理学和临床流行病学整合为一个研究肥胖的跨学科研究联盟 以及代谢综合征。我们的师资力量和管理部门的支持为我们提供了Tors 拥有专业知识、基础设施和能力来开发新方法来阐明和预防 与肥胖相关的疾病。成功完成这笔赠款中所述的研究将提供 需要对控制全身能量代谢的关键分子和途径有深入的了解，这将 被转化为开发预防肥胖和治疗新陈代谢的新方法 这种疾病的并发症。

Obesity and the constellation of associated metabolic risk factors (atherogenic dyslipidemia, hyperglycemia, hypertension, hepatic steatosis, prothrombotic and proinflammatory states) contribute importantly to death and disability in the United States. The mechanisms responsible for obesity and the metabolic syndrome have resisted elucidation through conventional approaches. Experts in the field have proposed that progress towards understanding the gene/environment interactions causing obesity will require the implementation of a broad-based clinical and basic research program. To develop such a program, we have assembled a highly interactive and collaborative interdisciplinary team of experts at UT Southwestern called the Taskforce for Obesity Researchat Southwestern (TORS). TORS harnesses expertise from highly diverse disciplines, with a goal of defining the behavioral, metabolic, genetic and molecular mechanisms contributing to obesity and the metabolic syndrome. Our accomplishments during the past 2 years of P20 funding demonstrate that we have successfully integrated traditionally disparate disciplines of anatomy, biochemistry, chemistry, genetics, lipid metabolism, molecular biology, intermediary metabolism, neuroendocrinology, nutrition, pharmacology, physiology, and clinical epidemiology into a cohesive Interdisciplinary Research Consortium to study obesity and the metabolic syndrome. The strength of our faculty and the support of our administration provide TORS with the expertise, infrastructure, and ability to develop new approaches to the elucidation and prevention of obesity-associated diseases. Successful completion of the studies described in this grant will provide much needed insights into the key molecules and pathways that govern whole-body energy metabolism, which will be translated into the development of new approaches to prevent obesity and to treat the metabolic complications of this disorder.