Nano Radioisotope Sources For Targeted Radiation Therapy

描述(申请人提供)：靶向治疗中使用的放射性同位素通常被标记为靶向生物分子。不同的放射性同位素和生物分子通常需要不同的连接来将放射性同位素结合到靶向生物分子上。这项拟议的研究是为了创造模块化的纳米放射性同位素来源，以提高肿瘤靶向性。利用纳米级的聚变，可以创造出一类新的、低成本的放射性同位素源，具有尽可能理想的能谱，并可以模块化和功能化，以彻底改变定向递送。拟议研究的第一阶段将侧重于纳米聚变放射性同位素源的创造和功能化。这些纳米放射性同位素可能是理想的功能化的模块化标记块，特别适用于靶向治疗。模块化和功能化的纳米放射性同位素源的体外表征将包括在模拟体液中测量放射性。将这种纳米融合的放射性同位素源标记到选定的生物分子上将是第二阶段研究的重点。与公共健康相关：肿瘤靶向类似于一枚瞄准并摧毁其目标的智能炸弹。复杂的是要发现在选定的放射性同位素(“炸弹”)和选定的靶向生物分子之间存在一种有效的连接。该项目在创建“即插即用”肿瘤靶向系统方面迈出了第一步，通过在纳米级使用聚变将放射性同位素源模块化，从而将与放射性同位素的连接简化为一种可靠和标准的连接。

DESCRIPTION (provided by applicant): Radioisotopes used in targeted therapy are often labeled to targeting biomolecules. Different radioisotope and biomolecule usually require different linkage to bind the radioisotope to the targeting biomolecule. This proposed research is to create modular nano radioisotope sources for improving tumor targeting. Using fusion at the nano-scale, a class of new and low cost radioisotope sources can be created with the most desirable energy spectrum possible and can be modularized and functionalized to revolutionize targeted delivery. Phase I of the proposed research will focus on the creation and functionalization of the nano-fused radioisotope sources. These nano radioisotopes are, potentially, ideal to be functionalized as a modular labeling block especially useful for targeted therapy. In vitro characterization of modularized and functionalized nano radioisotope sources will include radioactivity containment measurements in simulated body fluid. The labeling of such nano-fused radioisotope sources to selected biomolecules will be the focus of the Phase II research. PUBLIC HEALTH RELEVANCE: Tumor targeting is similar to a smart bomb aiming and destroying its target. The complication is to discover a working linkage to couple between a selected radioisotope (the "bomb") and a chosen targeting biomolecule. This project takes the first step in creating a "plug-and-play" tumor targeting system by modularizing radioisotope sources using fusion at the nano-scale such that linkages to radioisotopes are simplified to ONE reliable and standard linkage.