Identification of the conformation dependant targets of autoimmune disease linked variation in human regulatory T cells

被称为调节性T细胞的特殊免疫细胞充当免疫系统的警察，防止免疫系统攻击自己，但仍然与感染作斗争。如果这些细胞不能正常工作，就可能出现自身免疫性疾病，如1型糖尿病或IBD，因为免疫错误地攻击了正常的身体组织。为了解释这是如何出错的，我们需要仔细识别这些细胞中的所有基因相互作用，包括DNA中的长距离相互作用。

Specialised immune cells called regulatory T cells act as the policemen of the immune system, preventing the immune system attacking itself, but still fighting infections. If these cells do not work properly, autoimmune diseases such as type 1 diabetes or IBD can arise, because of immune attack on normal body tissue by mistake. In order to explain how this goes wrong we need to carefully identify all of the gene interactions in these cells including interactions over long distances in the DNA.