Diabetes and Tuberculosis Pilot

在临床结核病（TB）高危人群中筛查结核分枝杆菌感染是美国疾病控制与预防中心（CDC）控制结核病传播的一项关键策略。这在美国/墨西哥边境尤其重要，与美国全国平均水平相比，社会经济和人口因素的趋同导致了更高的结核病负担。该地区II型糖尿病（DB）的患病率也很高，长期以来人们都知道II型糖尿病易患活动性肺结核。基于这些信息，我们假设DB导致了墨西哥-美国边境四个德州县的西班牙裔人口的结核病负担。该试点项目将分析下大河谷（LRGV）的四个县：伊达尔戈、卡梅伦、威利西和

Screening for Mycobacterium tuberculosis infection in those at high risk for developing clinical tuberculosis (TB) is a key strategy of the Centers for Disease Control and Prevention (CDC) to control the spread of TB in the US. This is particularly important at the US/Mexico border, where converging socioeconomic and demographic factors contribute to the higher burden of TB when compared to the US national average. This region also has high prevalence of type II diabetes (DB), which has long been known to predispose to active tuberculosis. Based on this information, we hypothesize that DB contributes to the burden of TB in the Hispanic population from four Texan counties along the Mexican-American border. Four counties in the Lower Rio Grande Valley (LRGV) will be analyzed in this pilot project: Hidalgo, Cameron, WilIacy and Starr. A secondary analysis of the Texas hospital discharges during 2001 will be implemented using ICD 9 codes for case and control selection. Unconditional multiple logistic regression analysis will be used to evaluate the relationship between tuberculosis and tentative associated factors. Health production functions will be estimated, using unconditional multiple logistic regression as well. The specific aims of the project are: Aim 1: Determine the degree of association of DB and TB in Hispanics in the LRGV Aim 2: Determine the strength of the association between TB and its associated risk factors (besides DB), with emphasis on underlying medical conditions. Aim 3: Estimate health production function that will identify relevant socio-economic indicators of TB and DB.