SPF COLONY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的中心目标是繁殖无特定病原体（SPF）和具有遗传特征的SPF猕猴（主要是印度血统的恒河猴）-如RFA RR-02-005中国家研究资源中心所定义;特别是为NIH支持的艾滋病相关研究人员提供受试者，从而为国家卫生优先事项做出贡献。 YNPRC通过利用现有的SPF猕猴群来实现这一目标。 具体而言，通过繁殖、从YNPRC非SPF繁殖群招募幼仔以及通过适当的测试和分离来培养印度血统的SPF恒河猴群。该项目的总体目标是提供维持和扩大SPF繁殖群体所需的所有训练有素的人员和资源，并对其进行管理，以优化健康和生殖性能，支持NIH和NCRR确定的国家卫生相关优先事项。YNPRC将与NCRR及其设立的协调委员会密切合作，实施有关统一饲养程序、筛查测试标准化和委员会可能决定的其他事项的建议。YNPRC与维护NCRR支持的SPF菌落的其他设施以及NCRR确定的任何调查人员协调工作，以最大限度地实现SPF生产的国家优先事项。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central objective of this project is to breed SPF macaque monkeys (chiefly rhesus monkeys of Indian ancestry) that are specific pathogen free (SPF) and genetically characterized - as defined by the National Center for Research Resources in RFA RR-02-005; specifically to provide subjects to NIH supported investigators for AIDS related research and thus to contribute to national health priorities. This objective is achieved at the YNPRC by utilizing an existing colony of SPF macaque monkeys. Specifically, a colony of SPF rhesus of Indian ancestry is grown via breeding, recruitment of young animals from YNPRC non-SPF breeding colonies and via appropriate testing and separation. The overall aim of the project is to provide all the trained personnel and resources that are necessary to maintain and enlarge SPF breeding groups and to manage them in order to optimize health and reproductive performance in support of national health related priorities established by NIH and NCRR. The YNPRC will work closely with NCRR and the Coordinating Committee they have established in implementing recommendations regarding uniform husbandry procedures, standarization of screening tests and such other matters as the committee may decide. The YNPRC works in coordination with other facilities maintaining NCRR supported SPF colonies and with any investigators identified by NCRR to maximize the potential that national priorities for SPF production will be attained.