SUPPRESSION OF BREAKTHROUGH BLEEDING IN USERS OF PROGESTIN CONTRACEPTIVES

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 左炔诺孕酮（LNG） 释放植入物（例如Norplant）和释放LNG的宫内节育器（LNG-IUS;例如MirenaIUS）是女性避孕的有效方法。 然而，使用这些仅孕激素方法的妇女经常经历突破性子宫出血（BTB），这往往导致她们停止这种形式的避孕。 当用LNG-IUS治疗时，恒河猴也显示BTB，并且可以提供用于评估控制出血的疗法的动物模型。 我们在这项研究中的目标是利用恒河猴来表征LNG-IUS对子宫内膜的影响，并测试间歇性孕酮拮抗剂（PA）治疗LNG-IUS使用引发的BTB。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Levonorgestrel (LNG) releasing implants (e.g. Norplant), and LNG -releasing intrauterine devices (LNG-IUS; e.g. Mirena IUS) are effective methods of contraception for women. However, women using these progestin-only methods frequently experience breakthrough uterine bleeding (BTB) that often leads them to discontinue this form of contraception. Rhesus macaques also display BTB when treated with LNG-IUS, and can provide an animal model for assessing therapies to control the bleeding. Our goal in this research is to utilize rhesus macaques to characterize the effect of LNG-IUS on the endometrium and to test intermittent progesterone antagonist (PA) therapy as a treatment for BTB triggered by LNG-IUS use.