PRECLINICAL STUDIES ON NONHUMAN PRIMATE ENDOMETRIAL XENOGRAFTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 子宫内膜异位症是一种慢性疾病，其中子宫内膜样组织在子宫外部位形成病变。 我们的目标是测试子宫内膜异位症的潜在新疗法。 为此，我们开发了一种新的模型，其中恒河猴子宫内膜移植到免疫缺陷转基因RAG-2/cgamma KO小鼠，这是不能排斥异种移植物。 子宫内膜异种移植物对雌激素有反应，并经历类似于女性子宫内膜异位症的周期性分解。 我们的计划是用新的疗法治疗小鼠，包括孕激素受体（PR）A/B特异性配体，雌激素受体β拮抗剂等，我们的目的是在开发女性临床试验之前评估这些疗法的安全性和有效性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Endometriosis is a chronic disease where endometrium-like tissue forms lesions at sites outside the uterus. Our goal is to test potential new therapies for endometriosis. To do this, we developed a novel model in which rhesus macaque endometrium is transplanted into immunodeficient transgenic RAG-2/cgamma KO mice, which are incapable of rejecting xenografts. The endometrial xenografts grow in response to estrogen and undergo cyclic breakdown similar to endometriosis in women. Our plan is to treat the mice with novel therapies including progesterone receptor (PR) A/B-specific ligands, estrogen receptor beta antagonists, etc. Our aim is to assess the safety and efficacy of these therapies prior to developing clinical trials in women.