SUPPRESSION OF BREAKTHROUGH BLEEDING IN USERS OF PROGESTIN CONTRACEPTIVES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 释放左炔诺孕酮(LNG)的植入物(如NorPLANT)和释放LNG的宫内节育器(LNG-IUS；例如Mirena IUS)是妇女有效的避孕方法。然而，使用这些方法的妇女经常经历突破性子宫出血(BTB)，这往往导致她们停止这种形式的避孕。恒河猴在接受LNG-IUS治疗时也会出现BTB，并可以提供一个动物模型来评估控制出血的治疗方法。我们在这项研究中的目标是利用恒河猴来表征LNG-IUS对子宫内膜的影响，并测试间歇性孕激素拮抗剂(PA)治疗由LNG-IUS引发的BTB的效果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Levonorgestrel (LNG)-releasing implants (e.g. Norplant) and LNG-releasing intrauterine devices (LNG-IUS; e.g. Mirena IUS) are effective methods of contraception for women. However, women using these methods frequently experience breakthrough uterine bleeding (BTB) that often leads them to discontinue this form of contraception. Rhesus macaques also display BTB when treated with LNG-IUS, and can provide an animal model for assessing therapies to control the bleeding. Our goal in this research is to utilize rhesus macaques to characterize the effects of LNG-IUS on the endometrium and to test intermittent progesterone antagonist (PA) therapy as a treatment for BTB triggered by LNG-IUS use.