EXPANDING VIROLOGY IN THE NON-HUMAN PRIMATE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 非人灵长类(NHP)是人类的近亲，因此是生物医学研究的宝贵资源。在所有的NHP中，黑猩猩是人类最接近的亲戚，但将这种高度濒危的物种用于实验研究会带来伦理限制。或者，东半球猕猴，如恒河猴(Macaca Mulatta)(Rm)，代表了合适的动物模型，因为Rm与人类在遗传、生理和免疫方面有密切的相似之处。RM在研究人类生殖生物学和获得性免疫缺陷综合征(AIDS)发病机制方面的作用得到了很好的证明，但对于其他影响人类健康的疾病表现，如其他基于病毒和遗传的疾病，研究较少。这一发展建议的长期目标是进一步开发RM模型，用于阐明病毒疾病状态和评估应用于人类健康的基于病毒的疗法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Non-human primates (NHP) are close relatives to humans and because of this represent a valuable resource for biomedical research. Of all the NHP the chimpanzee is the closest relative of humans, but the usage of this highly endangered species for experimental research raises ethical constraints. Alternatively, Old World macaques, such as rhesus macaques (Macaca mulatta) (RM), represent suitable animal models as RM share close genetic, physiological and immunological similarities with humans. The utility of RM is well documented for studying aspects of human reproductive biology and acquired immunodeficiency syndrome (AIDS) pathogenesis, but is less developed for other disease manifestations that affect human health, such as other viral- and genetic-based disease conditions. The long-term goals of this developmental proposal are to further develop the RM model for elucidation of viral disease states and the evaluation of viral-based therapies for application to human health.