VALIDATING VIL-6 AS A TARGET FOR KSHV-ASSOCIATED DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 对恒河猴(RM)的初步研究表明，与单独感染SIV的恒河猴相比，实验感染Kaposi肉瘤相关疱疹病毒(KSHV)/人类疱疹病毒8(HHV-8)的猴免疫缺陷病毒(SIV)和恒河猴横纹病毒(RRV)可导致B细胞增殖。RRV和KSHV一样，编码白介素6(IL-6)同系物。KSHV IL-6同源物被认为是Kaposi肉瘤和B细胞来源的恶性肿瘤所必需的生长因子，B细胞来源的恶性肿瘤被称为体腔淋巴瘤或艾滋病患者中也感染KSHV的原发渗出性淋巴瘤。这项研究的长期目标是评估RRV IL-6同系物在SIV感染背景下病毒介导的B细胞增殖中的作用。这些研究的结果应该有助于阐明VIL-6在病毒感染中的作用，并为未来伽马-2疱疹病毒诱导的恶性肿瘤的诊断和治疗提供新的见解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preliminary studies in rhesus macaques (RM) reveal that RM experimentally infected with the simian immunodeficiency virus (SIV) and rhesus rhadinovirus (RRV), the homologue of Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 (HHV-8), develop B cell hyperplasia compared to RM infected with SIV alone. RRV, like KSHV, encodes an interleukin-6 (IL-6) homologue. The KSHV IL-6 homologue is thought to be a necessary growth factor for Kaposi's sarcoma and the B cell-derived malignancy referred to as body cavity-based lymphomas or primary effusion lymphoma in AIDS patients also infected with KSHV. The long-term objectives of this study aim to evaluate the role of the RRV IL-6 homologue in viral-mediated B cell hyperplasia in the context of an SIV infection. The results from these studies should help elucidate the role of the vIL-6 in virus infection and provide new insights into the future development of diagnostics and therapies for gamma-2 herpesvirus-induced malignancies.