GAMMA-2 HERPESVIRUS-ASSOCIATED JAPANESE MACAQUE ENCEPHALOMYELITIS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 特定的病毒，特别是γ-疱疹病毒，可以作为多发性硬化症（MS）的触发器。此外，越来越多的证据表明，MS的易感性可能与某些遗传位点的多态性有关，包括主要组织相容性复合体基因和白细胞介素-7受体α基因。在俄勒冈州国家灵长类动物研究中心的日本猕猴（JM）群体中，我们发现了一种自发发生在一小部分动物中的新型脑脊髓炎。这种疾病被称为日本猕猴脑脊髓炎（JME），以进行性和复发缓解型两种形式发生，其特征是脑和脊髓脱髓鞘，伴有广泛的星形胶质细胞增生。受影响的动物出现衰弱性运动和眼部障碍。通过磁共振成像（MRI）评价，该群体中约10%的动物似乎存在慢性亚临床病变。系谱分析表明，特定谱系的动物比其他动物更容易感染这种疾病，这表明JME的遗传易感性。此外，我们已经分离出一种γ-疱疹病毒，称为日本猕猴rhadinovirus（JMRV），从动物在这个殖民地，发现脱髓鞘的JME病变，而不是在未受影响的地区的大脑。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Particular viruses, especially gamma-herpesviruses, may act as a trigger of multiple sclerosis (MS). Furthermore, there is growing evidence that susceptibility to MS may be linked to polymorphisms at certain genetic loci, including major histocompatibility complex genes and the interleukin-7 receptor-alpha gene. We have characterized a novel encephalomyelitis that occurs spontaneously in a small percentage of animals in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. The disease, called Japanese macaque encephalomyelitis (JME), occurs in both progressive and relapsing-remitting forms and is characterized by brain and spinal cord demyelination that is accompanied by extensive astrogliosis. Affected animals develop debilitating motor and ocular disturbances. Approximately 10% of the animals in this colony appear to have chronic, subclinical lesions as evaluated by magnetic resonance imaging (MRI). Pedigree analysis indicates that particular lineages of animals are substantially more susceptible to this disease than others, suggesting a genetic predisposition to JME. Furthermore, we have isolated a gamma-herpesvirus, referred to as Japanese macaque rhadinovirus (JMRV), from animals in this colony that is found within demyelinated JME lesions and not within unaffected regions of the brain.