NDSU COMPUTATIONAL CHEMISTRY ANDBIOLOGY CORE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 北达科他州INBRE生物信息学核心旨在提高该州获得支持生物医学研究的计算和电子资源的能力。 其目的是：1）通过计算化学和生物学网络（CCBN）支持INBRE研究人员的计算需求; 2）通过从SGI/IRIX平台过渡到PC/Linux平台，并通过制定服务费计划，实现CCBN的可持续性;以及3）增强全州INBRE网络的电子资源和数据库的访问。 电子资源的透明性使北达科他州两所研究型大学之间的实质性合作成为可能。 以负担得起的获取为指导原则，UND和NDSU的研究人员以及更广泛的科学网络受益于可支配资源的增加。机构通过联营协议降低成本而受益。 为了满足对计算资源的预期增长需求，并控制支持CCBN的成本，CCBN将从目前的SGI/IRIX平台向PC/Linux平台进行重大转型。 届时，远程用户将能够使用标准PC访问最先进的分子建模，并利用现有和计划中的服务器和PC集群的计算能力。 在五年内实施使用费制度，将可应付CCBN日后的维修需要。作为INBRE电子资源计划的一部分，通过BRIN第一阶段购买的电子资源将成为制度化的，这将使INBRE图书馆联盟能够在未来五年内评估和收购其他重要的电子期刊和数据库，以支持生物医学研究界。将作出特别努力，以满足INBRE调查人员对电子资源的需求。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The North Dakota INBRE Bioinformatics Core is designed to enhance the state's access to computational and electronic resources supporting biomedical research. The aims are to: 1) support the computational needs of INBRE investigators through the Computational Chemistry and Biology Network (CCBN); 2) achieve sustainability of the CCBN by transitioning from an SGI/IRIX-platform to a PC/LINUX platform, and by instituting a service fee plan; and 3) enhance access to electronic resources and databases for the statewide INBRE network. The transparent nature of electronic resources makes substantive, cooperation between the two research universities in North Dakota feasible. With affordable access as the guiding principle, investigators at UND and NDSU and the wider scientific network benefit from increased resources at their disposal. Institutions benefit by being able to lower costs through consortium agreements. In order to meet the anticipated increase in demand for computational resources and to keep the cost of supporting the CCBN under control, the CCBN will undergo a major transformation from its current SGI/IRIX platform to a PC/LINUX platform. As this happens, remote users will be able to access state-of-the-art molecular modeling with standard PCs, and tap into the computing power of the existing and planned servers and PC clusters. Implementation of a user fee system over five years will meet the future maintenance needs of the CCBN. As part of the INBRE plan for electronic resources, electronic resources purchased through BRIN Phase I will become institutionalized, this will allow the INBRE library consortium to evaluate and acquire other critical electronic journals and databases over the next five years to support the biomedical research community. Special efforts will be made to meet the electronic resources needs of INBRE investigators.