WV-INBRE: MU & WVU BIOINFORMATICS CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 生物信息学核心支持获得序列和结构分析所需的软件和硬件工具，并提供这些领域的培训。Accelrys已宣布将不再支持GCG套餐。为了继续支持基于序列的工具，WV-INBRE将过渡到向量NTI。这个软件套装对学术界的研究人员免费提供。我们计划在暑期项目初期在领航机构(S)举办关于使用VectorNTI的研讨会(S)，以便暑期项目的参与者能够参加。用于Accelrys许可证的资金将被重新定向到PATHAYS软件的许可证(S)。我们正在评估两个系统：GeneGo MetaCore/MetaDrug套件(带有MetaRodent和MapEditor附加组件)和Invenity Path分析。这两者都可以作为基于Web的应用程序来实现。托管Accelrys GCG包的服务器将用于为西弗吉尼亚大学蛋白质组学核心提供生物信息学支持。此外，生物信息学核心正在为西弗吉尼亚大学蛋白质组学核心设施(在信号转导和癌症中心下建立)提供生物信息学分析支持。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Bioinformatics Core supports access to software and hardware tools needed for sequence and structure analysis and provides training in these areas. Accelrys has announced that it will no longer support the GCG package. To continue support of sequence-based tools, the WV-INBRE will transition to Vector NTI. This software suite is available to academia-based researchers without charge. We plan to host workshop(s) on use of VectorNTI at lead institution(s) early in the summer program so that summer program participants can attend. The funds used for the Accelrys license will be re-directed to license(s) for pathways software. We are evaluating two systems: the GeneGo MetaCore/MetaDrug suite (with MetaRodent and MapEditor add ons) and Ingenuity Pathway Analysis. Both of these can be implemented as web-based applications. The servers hosting the Accelrys GCG package will be used to for bioinformatics support of the WVU Proteomics Core. In addition, the Bioinformatics Core is providing bioinformatics analysis support for the WVU Proteomics Core facility (established under the Signal Transduction and Cancer COBRE).