LBRN: MOLECULAR CELL BIOLOGY CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 理论基础和具体目标 分子细胞生物学在遗传学、发育生物学、免疫学、神经生物学和癌症生物学等生物医学科学的重要基础领域之间提供了重要的联系。近年来，分子生物学原理和方法的应用极大地提高了我们对细胞和亚细胞水平上的各种细胞机制的理解，包括细胞周期、细胞分化、细胞发育、细胞衰老和细胞凋亡等现象。随着人类和其他动物基因组的阐明以及对所有形式的编码蛋白质的分析，不久将能够识别生物体可能合成的所有基因产物。基因组测序和蛋白质组分析产生的大量信息只有通过先进的生物计算/生物信息学方法才能有效地挖掘出来，这最终将把序列信息(基因组学)和蛋白质鉴定(蛋白质组学)与细胞范围内的生理功能联系起来。因此，分子细胞生物学是生物医学研究的新时代的中心。 我们选择了分子细胞生物学作为一个包罗万象的主题，其中包括所有参与机构的广泛研究兴趣，以及聚集的初级调查人员队伍的具体兴趣。例如，南方大学的PUI研究人员专注于分子和环境毒理学以及癌症生物学，而路易斯安那大学门罗分校的研究人员则研究天然产物化学和神经生物学。根据机构目标，显然将在参与机构内增加更多新的调查人员，以加强它们的分子细胞生物学计划。为了确保充分的人员培训和对个别项目的支持，以及促进所有研究人员之间的有效协调和沟通，包括与生物信息学/生物计算研究人员的协调和沟通，我们成立了分子和细胞生物学核心(MCBC)。 重要的是，INBRE MCBC利用了LSU-Tulane Cobre在实验传染病研究中的分子生物学和免疫学核心(LSU-MBIC)的技术优势和最先进的分子设施。该核心位于路易斯安那州立大学兽医学院生物技术和分子医学部(BIOMMED)内并由其管理(见下文BIOMMED描述)。在BIOMMED的指导下，LSU COBRE-MBIC和INBRE MCBC的整合旨在利用和扩大每个单位的现有资源和专门知识，协同增强两个核心的功能，同时最大限度地减少设备和服务的重复。此外，MCBC将协调和促进路易斯安那州立大学系统中其他中央设施提供的研究支持，以构建一个尽可能大的智力平台，在这个平台上，创新和创造性的想法将与最先进的技术相融合。对各个INBRE项目的有效协调和支持将为PUI调查人员提供最大可能的机会，为实现未来NIH的独立资助积累创新和有意义的初步数据。这种INBRECOBRE资源的交叉利用构成了NCRR的计划目标，可以有效地提高全州在生物医学科学方面的研究竞争力。 MCBC的具体目标是 具体目标一：通过提供先进的分子细胞生物学培训和使用最先进的设备，支持INBRE研究人员的研究努力和活动。 具体目标二：培训和发展一批足够数量的研究人员，他们将在PUI校园扩大由校外资助的分子细胞生物学研究的潜力。 具体目标三：协调和促进MCBC和其他INBRE调查人员之间的互动，以及INBRE调查人员和其他NIH资助的高级调查人员之间的互动。 具体目标四：协调和促进儿童权利委员会和英国广播公司INBRE专题领域的研究人员之间的合作研究工作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rationale and Specific Aims Molecular Cell Biology provides an essential linkage among important basic fields of biomedical sciences, such as genetics, developmental biology, immunology, neurobiology and cancer biology. In recent years, the application of molecular biological principles and methods has made it possible to vastly improve our understanding of various cellular mechanisms at cellular and subcellular levels including the phenomena of cell cycle, cell differentiation, cell development, cell aging and apoptosis. The elucidation of the human and other animal genomes in conjunction with analysis of all forms of the encoded proteins will soon enable the identification of all the gene products that are potentially synthesized by an organism. The vast information generated by genomic sequencing and proteomic analysis can be effectively mined only by advanced biocomputation/bioinformatics approaches, which will ultimately, connect sequence information (genomics) and protein identification (proteomics) to physiological function within the context of the cell. Therefore, molecular cell biology is at the center of a new era of biomedical research. We have chosen the theme of Molecular Cell Biology as an all encompassing theme that includes the broad research interests of all participating institutions, as well as the specific interests of the assembled cadre of junior investigators. For example, the PUI investigators at Southern University focus on molecular and environmental toxicology, as well as cancer biology, while those at the University of Louisiana at Monroe study natural products chemistry and neurobiology. Based on institutional goals, it is clear that additional new investigators will be added within participating institutions to enhance their molecular cell biology programs. To ensure ample personnel training and support of individual projects, as well as to facilitate effective coordination and communication among all researchers including coordination and communication with bioinformatics/biocomputation researchers, we have established a Molecular and Cell Biology Core (MCBC). Importantly, the INBRE MCBC takes advantage of the technological strengths and state-of-the-art molecular facilities of a Molecular Biology and Immunology Core (LSU-MBIC) of the LSU-Tulane COBRE in Experimental Infectious Disease Research. This Core is located within and administered by the Division of Biotechnology and Molecular Medicine (BIOMMED) at the LSU School of Veterinary Medicine (see BIOMMED description below). The integration of the LSU COBRE-MBIC and the INBRE MCBC under the direction of BIOMMED is intended to leverage and expand the available resources and expertise of each unit and to synergistically enhance the function of the two cores, while minimizing the duplication of equipment and services. In addition, the MCBC will coordinate and facilitate research support provided by other centralized facilities in the LSU system to structure the greatest possible intellectual platform upon which innovative and creative ideas will merge with state-of-the-art technologies. An effective coordination and support of individual INBRE projects will provide the maximum possible opportunity for the PUI investigators to accumulate innovative and meaningful preliminary data toward achieving future independent NIH funding. This INBRECOBRE resource cross-utilization constitutes NCRR programmatic goals that can effectively enhance statewide research competitiveness in the biomedical sciences. The specific aims of the MCBC are Specific Aim I: To support the research efforts and activities of the INBRE investigators by providing advanced molecular cell biology training and access to state-of-the-art equipment. Specific Aim II: To train and develop a critical mass of investigators who will expand the potential for extramurally-funded molecular cell biology research in PUI campuses. Specific Aim III: To coordinate and facilitate interactions among MCBC and other INBRE investigators, as well as between INBRE investigators and other senior NIH-funded investigators. Specific Aim IV: To coordinate and facilitate collaborative research endeavors between researchers of the MCBC and BBC thematic areas of the INBRE.