Molecular Biology and Immunopathology Core
分子生物学和免疫病理学核心
基本信息
- 批准号:10360594
- 负责人:
- 金额:$ 30.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-01 至 2026-02-28
- 项目状态:未结题
- 来源:
- 关键词:AdoptedBioinformaticsBiologicalBiological AssayBiomedical ResearchBiotechnologyCRISPR/Cas technologyCell Culture TechniquesCellsCellular biologyCenters of Research ExcellenceCollaborationsComputer softwareComputers and Advanced InstrumentationConsultConsultationsContract ServicesCore FacilityDataDiseaseDisease modelElectron MicroscopyEnsureEquipmentExperimental DesignsFacultyFaculty RecruitmentFundingGene ExpressionGenomicsGenus HippocampusGoalsHumanHuman ResourcesImmunofluorescence MicroscopyImmunologicsImmunologyInvestigationLaboratoriesLeadershipLifeLouisianaMaintenanceMalignant NeoplasmsMeasurementMeasuresMethodologyMethodsMolecularMolecular BiologyMolecular MedicineMonoclonal AntibodiesPathologyPatientsProductivityProteinsProteomicsQuantitative Reverse Transcriptase PCRReagentResearchResearch PersonnelResourcesReverse Transcriptase Polymerase Chain ReactionScienceServicesStudentsTechnical ExpertiseTechnologyTimeTissue SampleTrainingTraining ActivityTraining and EducationTreatment outcomeUnited States National Institutes of HealthUniversitiesUpdateVeterinary MedicineVeterinary SchoolsViral VectorWorkanimal imaginganimal tissueanticancer researchbasebioimagingcostcourse moduleexperimental studyimmunopathologyin vivoinstrumentationinterestnano-stringnew technologynovel therapeutic interventionpre-clinicalpreclinical evaluationpredictive modelingrepairedsingle cell sequencingtranscriptome sequencingtranscriptomics
项目摘要
Summary Molecular Biology Immunopathology Core.
The proposed Center for Pre-Clinical Cancer Research (Cancer COBRE) at Louisiana State University (LSU)
focuses on elucidating molecular and cellular mechanisms of human cancer using specialized disease models
that are predictive of disease in humans. The Cancer COBRE will focus on devastating human cancers that have
poor treatment outcome in patients in need of novel therapeutic strategies. The proposed projects led by highly
Promising Junior Investigators (PJIs) require the application of advanced molecular biological and
immunopathological principles, methods and particularly advances in genomics, transcriptomics and proteomics,
immunology and pathology to delineate key cellular mechanisms for each specific cancer necessitating access
to state-of-the-art equipment and technical expertise. The Molecular Biology and Immunopathology Core
(MBIPC) has been created to leverage and expand the resources and expertise of the Division of Biotechnology
and Molecular Medicine (BioMMED) at the LSU School of Veterinary Medicine (SVM), which administers six
Core Facilities: Gene Expression and Sequencing Laboratory (GeneLab), Viral Vectors Laboratory, Protein
Characterization and Purification laboratory (PCPL), which is also generates monospecific and monoclonal
antibodies to proteins of interest, the Small Animal Imaging Laboratory (SAIL) and the Molecular
Immunopathology laboratory (MIPL) that provides expertise in immunopathology and access to the SVM
Centralized Facilities (FACS and Pathology Cost Centers), and also provides expertise and access to bioimaging
and advanced immunofluorescence and electron microscopy. These laboratories are currently co-supported by
the Louisiana Biomedical Research Network (LBRN/INBRE), which also operates the LBRN Bioinformatics Core
in close collaboration with the LSU Center for Computation & Technology (CCT). The goal of MBIPC is to provide
and coordinate access to state of the advanced instrumentation and services and provide training in a broad
spectrum of fundamental and advanced molecular biology and immunopathology to all PJIs and other NIH-
funded investigators to achieve their research objectives. MBIPC has identified two specific aims:
Aim 1. To provide the Cancer COBRE and other NIH-funded investigators with resources and expertise in
molecular and cell biology and immunopathology including instrumentation, technical support, consultation and
training, and assistance in developing new methodologies.
Aim 2: To organize, coordinate, and facilitate interactions among COBRE investigators and work collaboratively
to develop and use new technologies and assays, and train PJIs, faculty, staff, and students in advanced
molecular biology and immunopathology technologies.
分子生物学免疫病理学核心。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Konstantin G Kousoulas其他文献
Hyperthermia-Mediated Cell Death in Murine GT1-7 Hypothalamic Neurons and Human LnCap Prostate Carcinoma Cells Exposed to Nanoparticles of SPIONs@Au-Cysteamine-LHRH
- DOI:
10.1016/j.freeradbiomed.2010.10.180 - 发表时间:
2010-01-01 - 期刊:
- 影响因子:
- 作者:
Faruq Mohammad;Sainath Babu;Achuthan C Raghavamenon;Kumar SSR Challa;Konstantin G Kousoulas;Rao M Uppu - 通讯作者:
Rao M Uppu
Konstantin G Kousoulas的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Konstantin G Kousoulas', 18)}}的其他基金
National IDeA Symposium of Biomedical Research Excellence - NISBRE
全国 IDeA 生物医学研究卓越研讨会 - NISBRE
- 批准号:
10318869 - 财政年份:2022
- 资助金额:
$ 30.67万 - 项目类别:
Characterization of Protective Immunity to MTB in a Setting of HIV Coinfection
HIV 合并感染情况下 MTB 保护性免疫的特征
- 批准号:
9302690 - 财政年份:2016
- 资助金额:
$ 30.67万 - 项目类别:
Correlates of protection from TB and TB/AIDS comorbidity
预防结核病和结核病/艾滋病合并症的相关性
- 批准号:
9302257 - 财政年份:2016
- 资助金额:
$ 30.67万 - 项目类别:
Center for Experimental Infectious Disease Research
实验传染病研究中心
- 批准号:
8857508 - 财政年份:2014
- 资助金额:
$ 30.67万 - 项目类别:
Center for Experimental Infectious Disease Research
实验传染病研究中心
- 批准号:
8711688 - 财政年份:2014
- 资助金额:
$ 30.67万 - 项目类别:
相似海外基金
Collaborative Research: IIBR: Innovation: Bioinformatics: Linking Chemical and Biological Space: Deep Learning and Experimentation for Property-Controlled Molecule Generation
合作研究:IIBR:创新:生物信息学:连接化学和生物空间:属性控制分子生成的深度学习和实验
- 批准号:
2318829 - 财政年份:2023
- 资助金额:
$ 30.67万 - 项目类别:
Continuing Grant
Analysis of biological small molecule mixtures using multiple modes of mass spectrometric fragmentation coupled with new bioinformatics workflows
使用多种质谱裂解模式结合新的生物信息学工作流程分析生物小分子混合物
- 批准号:
BB/X019802/1 - 财政年份:2023
- 资助金额:
$ 30.67万 - 项目类别:
Research Grant
Collaborative Research: IIBR: Innovation: Bioinformatics: Linking Chemical and Biological Space: Deep Learning and Experimentation for Property-Controlled Molecule Generation
合作研究:IIBR:创新:生物信息学:连接化学和生物空间:属性控制分子生成的深度学习和实验
- 批准号:
2318830 - 财政年份:2023
- 资助金额:
$ 30.67万 - 项目类别:
Continuing Grant
Collaborative Research: IIBR: Innovation: Bioinformatics: Linking Chemical and Biological Space: Deep Learning and Experimentation for Property-Controlled Molecule Generation
合作研究:IIBR:创新:生物信息学:连接化学和生物空间:属性控制分子生成的深度学习和实验
- 批准号:
2318831 - 财政年份:2023
- 资助金额:
$ 30.67万 - 项目类别:
Continuing Grant
Bioinformatics-powered genetic characterization of the impact of biological systems on Alzheimer's disease and neurodegeneration
基于生物信息学的生物系统对阿尔茨海默病和神经退行性疾病影响的遗传表征
- 批准号:
484699 - 财政年份:2022
- 资助金额:
$ 30.67万 - 项目类别:
Operating Grants
REU Site: Bioinformatics Research and Interdisciplinary Training Experience in Analysis and Interpretation of Information-Rich Biological Data Sets (REU-BRITE)
REU网站:信息丰富的生物数据集分析和解释的生物信息学研究和跨学科培训经验(REU-BRITE)
- 批准号:
1949968 - 财政年份:2020
- 资助金额:
$ 30.67万 - 项目类别:
Standard Grant
REU Site: Bioinformatics Research and Interdisciplinary Training Experience in Analysis and Interpretation of Information-Rich Biological Data Sets (REU-BRITE)
REU网站:信息丰富的生物数据集分析和解释的生物信息学研究和跨学科培训经验(REU-BRITE)
- 批准号:
1559829 - 财政年份:2016
- 资助金额:
$ 30.67万 - 项目类别:
Continuing Grant
Bioinformatics Tools to Design and Optimize Biological Sensor Systems
用于设计和优化生物传感器系统的生物信息学工具
- 批准号:
416848-2011 - 财政年份:2011
- 资助金额:
$ 30.67万 - 项目类别:
University Undergraduate Student Research Awards
ABI Development: bioKepler: A Comprehensive Bioinformatics Scientific Workflow Module for Distributed Analysis of Large-Scale Biological Data
ABI 开发:bioKepler:用于大规模生物数据分布式分析的综合生物信息学科学工作流程模块
- 批准号:
1062565 - 财政年份:2011
- 资助金额:
$ 30.67万 - 项目类别:
Continuing Grant
Bioinformatics-based hypothesis generation with biological validation for plant stress biology
基于生物信息学的假设生成和植物逆境生物学的生物验证
- 批准号:
261818-2006 - 财政年份:2010
- 资助金额:
$ 30.67万 - 项目类别:
Discovery Grants Program - Individual