X-RAY SPECTROSCOPY OF IRON FROM MOON DUST SIMULANTS INCORPORATED INTO LIVING TIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 自从阿波罗任务以来，月球尘埃就一直给太空探索带来了问题。其独特的粘附性和研磨性使其对航天服材料、生命维持系统和宇航员健康构成危害。随着美国宇航局S重返月球计划的实施，人们对月尘作为影响人类探索月球的一个因素的担忧变得迫切起来。月球尘埃含有潜在有毒的铁。果蝇可以作为生物传感器来测量月尘的铁毒性。携带导致亨廷顿S神经退行性疾病的人类基因的果蝇是铁毒性的敏感指标。同步辐射特别适用于小型活体样品的精细元素分析。X射线荧光光谱可用于定位铁在果蝇组织中的沉积，并获得铁的原位形态光谱。长期目标是开发果蝇作为传感器，以减轻月球尘埃的毒性，以便在未来的月球任务中成为科学有效载荷。这将允许在月球表面测量活体月球尘埃的毒性，并测试减轻其毒性影响的对策。该项目的目的是通过使用X射线荧光光谱和元素测绘来确定月球尘埃中的铁进入生物组织，从而对月球尘埃的地球化学性质和毒性提供基本的见解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lunar dust has raised issues for space exploration ever since the Apollo missions. Its unique adhesive and abrasive properties make it a hazard for space suits materials, life support systems and astronaut health. With NASA?s program for returning to the Moon, the concerns for the lunar dust as a factor affecting human exploration of the Moon have become pressing. Lunar dust contains iron with toxic potential. The fruit fly Drosophila can be used as a biological sensor to measure the iron toxicity of lunar dust. Fruit flies carrying the human gene responsible for the Huntington?s neurodegenerative disease are sensitive indicators of the toxicity of iron. Synchrotron radiation is uniquely suitable for refined elemental analysis of small living specimens. X-ray fluorescence spectroscopy can be used to localize the deposition of iron into fruit fly tissues and to obtain spectra to speciate iron in situ. The long-term goal is to develop the fruit fly as a sensor the toxicity of lunar dust to be available for a science payload on a future lunar mission. This would allow measuring the toxicity of lunar dust in vivo on the surface of the Moon and test countermeasures to mitigate its toxic effects. The objective of this project is to provide fundamental insight into the geochemical properties and toxicity of lunar dust by using x-ray fluorescence spectroscopy and elemental mapping to determine the incorporation of iron from lunar dust into living tissues.