STRUCTURAL STUDIES OF N EUROPEA RH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 Rh蛋白是一种完整的膜蛋白，其最明显的作用是作为一种血液因子，决定血液的(+/-)表型(如O+，O-)。库斯图实验室最近的功能研究表明，Rh蛋白是二氧化碳的通道。虽然已经确定了两个遥远的同源物AmtB和AMT-1的结构，但这些AMT蛋白是氨和/或甲胺通道。该项目的目标是确定第一个Rh结构蛋白的结构，并阐明导致其不同功能的特征。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rh proteins are integral membrane proteins whose most visible role is as a blood factor that determines the (+/-) phenotype of blood (e.g. O+, O-). Recent functional studies by the Kustu laboratory has shown that Rh proteins are CO2 channels. While the structure of two distant homologs, AmtB and Amt-1, have been determined, these Amt proteins are ammonia and/or methylamine channels. The goals of this project are to determine the structure of the first Rh structure protein and to elucidate the features that lead to their distinct functions.