SIGNALING AND ACTIN NUCELATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 Nck分子已成为受体激活的细胞骨架重组的重要调节剂。特别地，含有nNck结合结构域的受体复合物的聚集在聚集位点产生肌动蛋白聚合的彗星尾。我们将用虚拟细胞来模拟这个系统，试图剖析这种行为背后的复杂信号网络

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Nck molecule has emerged as an important regulator of receptor activated cytoskeletal reorganization. In particular, aggregation of a receptor complex containing a nNck binding domain produces comet tails of actin polymerization at the site of aggregation. We will model this system with the Virtual Cell in an effort to dissect th complex signaling network underlying this behavior