DENDRITIC CA SIGNALS IN STRIATAL MEDIUM SPINY NEURONS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们想把树突棘作为兴奋性突触，以及与之相关的树突。虚拟单元以电压敏感方式对离子通量进行建模的能力提供了一个强大且独特的框架来实现这一目标。具体目标将是用以下物质对生理学上准确的CA 1锥体神经元脊区室进行建模：谷氨酸受体（AMPAR、NMDAR（具有电压依赖性））、适当的电压敏感性钙通道（CaV 3、CaV 1.2/1.3和CaV 2.2/2.3）和SK通道（具有细胞内Ca依赖性）。还需要精确地模拟局部Ca缓冲和扩散。我们还希望包括一个树突室，是电气和扩散耦合到脊柱。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We would like to model a dendritic spine as an excitatory synapse, and its associated parent dendrite. Virtual Cell's ability to model ion flux in a voltage sensitive manner gives a powerful and unique framework to do so. The specific goal would be to model a physiologically accurate CA1 pyramidal neuron spine compartment with the following: glutamate receptors (AMPARs, NMDARs (with voltage dependence)), the appropriate voltage sensitive calcium channels (CaV3, CaV1.2/1.3 and CaV2.2/2.3), and SK channels (with intracellular Ca dependence). It is also necessary to accurately model local Ca buffering and diffusion. We would also like to include a dendrite compartment that is electrically and diffusionally coupled to the spine.