HIGH PERFORMANCE COMPUTING INFRASTRUCTURE FOR THE VIRTUAL CELL

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 VCell的基础设施（从一开始就作为一个分布式的、基于网络的客户端-服务器环境部署）以及相关的在线文件和培训材料已经存在了9年多。 随着虚拟小区平台不断增加新功能和能力，以及VCell用户数量的增长，需要不断增加CCAM计算设施中VCell服务器端的计算资源。 我们的计算设施是UCHC目前最大的高性能计算资源，包括为软件开发团队和协作项目提供企业计算支持。 我们托管和管理多个计算集群，总计超过300个CPU，一个52 CPU的生物信息学集群，两个入门级64位超级计算机（一个16 CPU/96 GB RAM的Itanium 2系统和一个8 CPU/64 GB RAM的Xeon MP系统），以及一个具有40 TB以上共享RAID存储容量的iSCSI SAN。 该设施的企业系统，如2个AD域，3个C类主机，100多个工作站，以及30多个专用32位和64位Xeon和Opteron服务器服务器，提供网络托管（5个域，2个维基），数据库托管和管理（Oracle和MySQL），远程访问（VPN，FTP，http dropbox），实验和模拟数据存储，代码库（Envy、ClearCase、SVN）、远程备份、共享访问控制、许可证管理和OpenScienceGrid的网格计算基础设施部分。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The infrastructure for VCell (which was deployed from the inception as a distributed, web-based client-server environment), as well as associated online documentation and training material have now been in place for over 9 years. Continuous additions of new features and capabilities to the Virtual Cell platform as well as the growth in the number of VCell users has required a constant increase in the computational resources of the VCell server side housed at the CCAM Computational Facility. Our Computational Facility is currently the largest resource for High Performance Computing at UCHC, and includes enterprise computing support for the software development team and collaborative projects. We host and manage several compute clusters totaling >300 CPUs, a 52-CPU bioinformatics cluster, 2 entry-level 64-bit supercomputers (a 16 CPU/96 GB RAM Itanium2 system an 8 CPU/64 GB RAM Xeon MP system), and an iSCSI SAN with 40+ TB of shared RAID storage capacity. The facilitie's enterprise systems, such as 2 AD domains, 3 class C subnets, 100+ workstations, and 30+ dedicated 32-bit and 64-bit Xeon and Opteron servers servers, provide for web hosting (5 domains, 2 wikis), database hosting and management (Oracle and MySQL), remote access (VPN, FTP, http dropbox), experimental and simulation data storage, code repositories (Envy, ClearCase, SVN), remote backup, shared access control, license management, and a grid computing infrastructure part of OpenScienceGrid.