BIOMED WORKSHOP: JUNE 25-29, 2007 COMPUTATIONAL METHODS FOR SPATIALLY REALISTI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 他的研讨会将涵盖以神经传递、信号级联和其他形式的生化网络等扩散-反应系统为重点的模型设计和模拟的理论和实践(例如，Coggan等人，2005，Science 309：446-451；He等人，2006，Nature 444：102-105)。将介绍当前版本的Mcell/DReAMM模拟环境(www.mcell.psc.edu和www.mcell.cnl.salk.edu)，包括用于溶液中和任意形状生物表面上的反应的三维模拟的新蒙特卡罗方法，以及用于模型设计和可视化的新工具。从解剖重建工具和计算机辅助设计工具创建的模型将被涵盖。根据2006年6月一个类似的非常成功的研讨会的反馈，该研讨会已延长到整整五天，并将强烈鼓励与会者为他们自己的模拟项目带来想法/数据。每天的课程表将包括理论和实践讲座、由讲师指导的实践教程，以及与讲师就个别项目开发进行一对一互动的机会。主要讲师将是乔尔·斯泰尔斯(国家生物医学超级计算资源)和托马斯·巴托尔(索尔克研究所计算神经生物学实验室)，他们是Mcell和DReAMM的原始开发者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. his workshop will cover theory and practice for the design and simulation of models focused on diffusion-reaction systems such as neurotransmission, signaling cascades, and other forms of biochemical networks (e.g., Coggan et al., 2005, Science 309:446-451; He et al., 2006, Nature 444:102-105). Current versions of the MCell/DReAMM simulation environment (www.mcell.psc.edu and www.mcell.cnl.salk.edu) will be introduced, including new Monte Carlo methods for 3-D simulation of reactions in solution and on arbitrarily shaped biological surfaces, as well as new tools for model design and visualization. Models created from both anatomical reconstruction tools and computer-aided design tools will be covered. Based on feedback from a similar highly successful workshop in June 2006, this workshop has been extended to five full days, and attendees will be strongly encouraged to bring ideas/data for their own simulation projects. The daily schedule will include theoretical and practical lectures, instructor-guided hands-on tutorials, and opportunities for one-on-one interaction with the instructors on individual project development. The primary instructors will be Joel Stiles (National Resource for Biomedical Supercomputing) and Thomas Bartol (Computational Neurobiology Laboratory, The Salk Institute), the original developers of MCell and DReAMM.