INTER-SITE QA DEVELOPMENT FOR THE FIRST BIRN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 第一个(功能成像研究精神分裂症试验床)生物医学信息学研究网络计划是有史以来第一个大规模、多中心的精神分裂症功能磁共振研究(http://www.nbirn.net).FBIRN项目将汇集11个参与站点中每个站点的fMRI数据，以便在适当的时间段内获得大量和多样化的研究人群。我们的中心一直负责对多中心功能磁共振成像试验至关重要的校准和质量保证方面的工作，G.格洛弗是fBIRN内校准工作组的主席。 这个子项目是关于使用屏气(BH)来校准和减轻受试者之间血流动力学差异的混杂影响的研究，从而减少差异并提高在大量人群中汇集数据的能力。以前的活动已经制定了基本方法，该联盟目前正在使用这种方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The FIRST (Functional Imaging Research Schizophrenia Testbed) Biomedical Informatics Research Network (fBIRN) program is the first-ever large scale, multi-center fMRI study of schizophrenia (http://www.nbirn.net). The fBIRN project will pool fMRI data from each of the 11 participating sites to enable the acquisition of a large and diverse study population in a modest time period. Our Center has been responsible for the calibration and quality assurance aspects important for multi-center fMRI trials, and G. Glover chairs the Calibration Working Group within the fBIRN. This subproject is a study of the use of breath holding (BH) to calibrate and mitigate the confounding effects of hemodynamic differences between subjects, thereby reducing variance and improving the ability to pool data across large populations. Previous activities have developed the basic method, which is in current use by the consortium.