课题基金 / 基金详情

ORIGINS OF STEREO-SELECTIVE CATALYSIS BY ANTIBODIES

ORIGINS OF STEREO-SELECTIVE CATALYSIS BY ANTIBODIES
抗体立体选择性催化的起源
批准号：
7722326
负责人：
KENDALL N HOUK
金额：
$0.32万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-05-01 至 2009-04-30
来源：
https://reporter.nih.gov/project-details/7722326
关键词：
AntibodiesAntibody Binding SitesCatalysisComputer Retrieval of Information on Scientific Projects DatabaseDockingFundingGoalsGrantInstitutionReactionResearchResearch PersonnelResearch Project GrantsResourcesSourceStructureUnited States National Institutes of Healthcatalystinsightquantum

项目摘要

项目成果

KENDALL N HOUK的其他基金

相似基金

相关文献

中文摘要
翻译
这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 使用Autodock和Autodock工具箱(ADT)研究抗体催化作用。这涉及到量子力学计算的过渡结构对接到抗体结合部位，以获得对立体选择性催化的见解。本研究项目的目的是了解抗体催化剂加速反应和诱导立体选择性的机制。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Using Autodock and Autodock Toolkit (ADT) to study antibody catalysis. This involves quantum mechanically computed transition structures docked into antibody binding sites to obtain insights into stereoselective catalysis. The goal of this research project is to understand the mechanism by which antibody catalysts accelerate the reaction and induce stereoselectivity.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Steroselectivity of Synthetically Valuable Enzyme Catalysts
Bioorthogonal Cycloadditions
Bioorthogonal Cycloadditions
Mapping the Evolution of a Novel Enzyme by Experiment and Computation
海外基金