NEW CHEMISTRY FOR MULTIPROTEIN COMPLEXES

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 Kodadek博士实验室的一个基本目标是设计出与任何所需蛋白质具有高亲和力和特异性结合的分子。这些试剂的最终应用将是构建先进的诊断设备，用于基于蛋白质的模式识别。如果可以为许多蛋白质鉴定出特定的配体，那么似乎可以识别标记并用于诊断。可以设计低分子量的人工抗体，但重要的问题是检测与靶蛋白的结合事件。该应用程序测试了使用MRI用于此目的的可行性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A fundamental goal of Dr. Kodadek's lab is to design molecules that bind with high affinity and specificity to any desired protein. The ultimate application of such reagents would be in the construction of advanced diagnostic devices that would be employed for protein-based pattern recognition. If specific ligands could be identified for many proteins, then it seems likely that signatures could be recognized and used diagnostically. Low molecular weight artificial antibodies can be designed, but an important problem is detecting the binding event with the target protein. This application tests the feasibility of using MRI for this purpose.