VASOREACTIVITY OF CEREBRAL HEMODYNAMICS-NEONATES WITH CONGENITAL HEART DEFECTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 观察到新生儿心脏手术幸存者的神经发育受损的结果 治疗先天性心脏病。有先验证据表明术前检查的重要性 大脑健康状况对观察结果的影响。此外，众所周知，外科手术 包括心脏旁路、深冷和停搏在内的参数需要通过 实时的床边监控。一个在很大程度上无法获得的关键参数是大脑 血流量(CBF)。我们最近开发了漫相关光谱(DCS)，用于 无创、连续测量相对脑血流量。这项工作的主要目标是 应用分布式控制系统检测新生儿脑血流动力学的血管反应性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Impaired neurodevelopmental outcome has been observed for survivors of neonatal heart surgery for congenital heart defects. There is prior evidence indicating the importance of preoperative cerebral well-being on the observed outcome. Furthermore, it is well known that the surgical parameters which include cardiac by-pass, deep-cooling and arrest need to be optimized via real-time, bed-side monitoring. A crucial parameter that is largely inaccessible is the cerebral blood flow (CBF). We have recently developed diffuse correlation spectroscopy (DCS) for non-invasive, continuous measurement of relative CBF. The primary objective of this work is to measure vasoreactivity of cerebral hemodynamics in neonates using DCS.