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Identification of germline variation that predicts progression free survival following chemotherapy for advanced ovarian cancer

Identification of germline variation that predicts progression free survival following chemotherapy for advanced ovarian cancer
鉴定预测晚期卵巢癌化疗后无进展生存期的种系变异
批准号:
nhmrc : 1051698
负责人:
A/Pr Juliet French
金额:
$42.22万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31

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中文摘要
翻译
被诊断为卵巢癌的女性通常会接受手术,然后进行化疗。然而,化疗的疗效差异很大,一些女性反应良好,而另一些女性则暴露在对她们几乎没有好处的治疗的毒副作用中。我们的目标是找出解释为什么会有反应差异的基因。这将导致更个性化的化疗,并改善卵巢癌女性的预后。
英文摘要
Women diagnosed with ovarian cancer typically undergo surgery, followed by chemotherapy. However, the efficacy of chemotherapy varies widely, with some women responding well, whilst others are exposed to the toxic effects of a treatment that does them little good. We aim to identify the genes which explain why there are differences in response. This will lead to more individualised chemotherapy and improved outcomes for women with ovarian cancer.
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会议论文
Exploring the Function of Breast Cancer-Associated Variants in Long Non-Coding RNAs
Post-GWAS Functional Characterisation of Breast Cancer Susceptibility Loci
Functional analysis of breast cancer susceptibility regions
Identifying long-range regulatory elements of the breast cancer susceptibility gene, BRCA1
  • 批准号:
    nhmrc : 631381
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $40.86万
  • 财政年份:
    2010
  • 负责人:
    A/Pr Juliet French
  • 依托单位:
国内基金
海外基金
原生动物四膜虫生殖小核(germline nucleus)体功能(somatic function)的分子基础研究